ヘスペレチン 化学特性,用途語,生産方法
外観
白色～うすい黄色、結晶性粉末～粉末
溶解性
ジメチルスルホキシドに溶ける。
解説
ヘスペレチン,無色の針状または板状晶．融点227～228 ℃．[α]D－37.6°(エタノール)．λmax 289 nm(log ε 4.27)．エタノール，エーテルに可溶，クロロホルム，ベンゼンに不溶．希アルカリ水溶液に鮮黄色に溶解し，酸を加えれば析出する．
森北出版「化学辞典（第2版）
用途
酸化防止剤
製造
ヘスペレチン,配糖体のヘスペリジンとして，多くの植物，とくにミカン属の植物の外果皮に含まれるほか，ペルシシン(persicin，C22H24O11，ヘスペレチングルコシド)として，モモPrunus persica L.の樹皮にも含まれる．
使用上の注意
アルゴン封入
説明
Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels,
ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC
50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.
化学的特性
Beige to Light Brown Crystalline Solid
使用
(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
定義
ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).
純化方法
Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]
ヘスペレチン 上流と下流の製品情報
原材料
準備製品