エンタカポン
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- CAS番号.
- 130929-57-6
- 化学名:
- エンタカポン
- 别名:
- エンタカポン;エンタカポン (JAN);(E)-エンタカポン;N,N-ジエチル-α-シアノ-3,4-ジヒドロキシ-5-ニトロ-trans-シンナムアミド;(2E)-2-シアノ-N,N-ジエチル-3-(3,4-ジヒドロキシ-5-ニトロフェニル)プロペンアミド;(2E)-2-シアノ-N,N-ジエチル-3-(3,4-ジヒドロキシ-5-ニトロフェニル)プロパ-2-エンアミド;(2E)-2-シアノ-3-(3,4-ジヒドロキシ-5-ニトロフェニル)-N,N-ジエチルプロパ-2-エンアミド;(E)-2-シアノ-N,N-ジエチル-3-(3,4-ジヒドロキシ-5-ニトロフェニル)プロペンアミド;コムタン;α-シアノ-N,N-ジエチル-3-ニトロ-4,5-ジヒドロキシ-trans-シンナムアミド
- 英語名:
- Entacapone
- 英語别名:
- (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide;Comtan;Comtes; OR-611;Comtess;HSDB8251;HSDB 8251;HSDB-8251;ENTACAPONE;E Entacapone
- CBNumber:
- CB5726435
- 化学式:
- C14H15N3O5
- 分子量:
- 305.29
- MOL File:
- 130929-57-6.mol
- MSDS File:
- SDS
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エンタカポン 物理性質
- 融点 :
- 162-1630C
- 沸点 :
- 526.6±50.0 °C(Predicted)
- 比重(密度) :
- 1.392±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：可溶20mg/mL、透明
- 外見 :
- 粉
- 酸解離定数(Pka):
- pKa ~4.5(at 25℃)
- 色:
- 白から薄茶色
- 安定性：:
- DMSO溶液またはエタノール溶液で-20°Cで最大1か月保存できます。
- InChIKey:
- JRURYQJSLYLRLN-BJMVGYQFSA-N
- CAS データベース:
- 130929-57-6(CAS DataBase Reference)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY14153 |
Entacapone |
130929-57-6 |
10mg |
￥12300 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY14153 |
Entacapone |
130929-57-6 |
25mg |
￥18800 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0654 |
エンタカポン ≥98% (HPLC)
Entacapone ≥98% (HPLC) |
130929-57-6 |
10mg |
￥14900 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
Y0001249 |
エンタカポン European Pharmacopoeia (EP) Reference Standard
Entacapone European Pharmacopoeia (EP) Reference Standard |
130929-57-6 |
y0001249 |
￥24800 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
1235933 |
エンタカポン United States Pharmacopeia (USP) Reference Standard
United States Pharmacopeia (USP) Reference Standard |
130929-57-6 |
200MG |
￥106000 |
2024-03-01 |
購入 |
エンタカポン 化学特性,用途語,生産方法
効能
パーキンソン病治療薬, 抗ジスキネジア, COMT阻害薬
商品名
コムタン (ノバルティスファーマ)
説明
Entacapone was introduced in Finland, Germany and Sweden as an
adjunctive treatment with L-dopa in Parkinson’s disease. Entacapone is the
second drug in its class to reach the market; it can be obtained by
basecatalyzed condensation of the corresponding benzaldehyde with a
cyanoacetamide. Entacapone is a highly selective and orally-active catechol-0-
methyltransferase (COMT) inhibitor ; by inhibiting metabolism of L-dopa when
given as an adjuvant in patients with Parkinson’s disease, Entacapone markedly
prolongs the effects of L-dopa and improves its bioavailability. Results from
clinical studies showed that 200mglday Entacapone coadministered with L-dopa
lowered the dose of the latter required to reduce fluctuations in motor
performance.
化学的特性
Yellow Crystalline Solid
使用
(E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian
定義
ChEBI: A monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5
nitrophenyl group.
一般的な説明
Entacapone, (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide (Comtan),is a nitrocatechol that is practically insoluble in water (pK
a＝4.50). Entacapone is rapidly absorbed after oral administrationand does not cross the BBB. Entacapone does not distributewidely into tissues because of its high plasma proteinbinding and it is completely metabolized before excretion.The main metabolic pathway is by isomerization to the cisisomerfollowed by direct glucuronidation of the parent andthe cis-isomer. The glucuronide conjugates are inactive.Entacapone is eliminated in the feces (90%) and urine (10%).Entacapone is indicated as an adjunct to levodopa/carbidopato treat patients with idiopathic PD who experience the signsand symptoms of end-of-dose wearing off.
エンタカポン 上流と下流の製品情報
原材料
準備製品
エンタカポン 生産企業
Global( 473)Suppliers
130929-57-6(エンタカポン)キーワード:
- 130929-57-6
- (E)-2-Cyano-3-(3，4-dihydroxy-5-nitrophenyl)-N，N-diethyl-2-pmpenamide
- Entacapone (150 mg)
- (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enaMide
- 2-PropenaMide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-
- Entacapone (isomer E)
- (E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide
- ENTACAPONE
- 2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enamide
- OR-611
- (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
- Comtes
- Comtess
- ENTACAPONE F·S
- Entacapone CRS
- Entacapone USP/EP/BP
- Entacapone Impurity 81
- Entacapone Impurity 82
- Entacapone Impurity 83
- E Entacapone
- Entacapone (OR611)
- EntacaponeQ: What is
Entacapone Q: What is the CAS Number of
Entacapone Q: What is the storage condition of
Entacapone Q: What are the applications of
Entacapone
- Entacapone (Y0001249)
- Entacapone (1235933)
- Comtan
- (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
- Well he carpenters
- Entacapone (API)
- (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide[OR-611
- HSDB 8251
- HSDB8251
- エンタカポン
- エンタカポン (JAN)
- (E)-エンタカポン
- N,N-ジエチル-α-シアノ-3,4-ジヒドロキシ-5-ニトロ-trans-シンナムアミド
- (2E)-2-シアノ-N,N-ジエチル-3-(3,4-ジヒドロキシ-5-ニトロフェニル)プロペンアミド
- (2E)-2-シアノ-N,N-ジエチル-3-(3,4-ジヒドロキシ-5-ニトロフェニル)プロパ-2-エンアミド
- (2E)-2-シアノ-3-(3,4-ジヒドロキシ-5-ニトロフェニル)-N,N-ジエチルプロパ-2-エンアミド
- (E)-2-シアノ-N,N-ジエチル-3-(3,4-ジヒドロキシ-5-ニトロフェニル)プロペンアミド
- コムタン
- α-シアノ-N,N-ジエチル-3-ニトロ-4,5-ジヒドロキシ-trans-シンナムアミド