ドルテグラビル

ドルテグラビル 価格 もっと(2)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01COBQJ-8807	ドルテグラビル Dolutegravir	1051375-16-6	100mg	￥709200	2018-12-26	購入
富士フイルム和光純薬株式会社(wako)	W01MAS125270	ドルテグラビル Dolutegravir	1051375-16-6	1g	￥5749900	2018-12-26	購入

ドルテグラビル 化学特性,用途語,生産方法

効能

抗ウイルス薬, HIVインテグラーゼ阻害薬

説明

In August 2013, the US FDA approved dolutegravir (also referred to as S/GSK1349572) for the treatment of HIV-1 infection in adults and children ages 12 years and older in combination with other antiretroviral drugs. Dolutegravir was approved in Canada in November 2013. HIV/AIDS remains a global epidemic with 35 million people infected, including 2.3 million new infections as of 2012. Dolutegravir joins raltegravir and elvitegravir (this chapter of ARMC) as the latest of three FDA-approved HIV integrase strand transfer inhibitors (INSTIs). Dolutegravir was discovered by rational design from a literature diketo acid HIV integrase inhibitor utilizing X-ray coordinates to predict ideal bond angles between the diketone and distal benzyl group. In dolutegravir, the monocyclic component of the reported inhibitor was replaced with the tricyclic carbamoyl pyridone moiety. The researchers postulated that the appropriate arrangement of three oxygens would permit chelation with two magnesium ions in the binding site thus affording improved potency. Ultimately, this arrangement along with further modifications afforded dolutegravir, a potent inhibitor of HIV integrase (IC₅₀=1.7 nM).

化学的特性

White Solid

定義

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]ox zine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1.

ドルテグラビル 上流と下流の製品情報

原材料

準備製品

ドルテグラビル 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
AFINE CHEMICALS LIMITED	+86-0571-85134551	info@afinechem.com	China	15396	58
Guangzhou Tengyue Chemical Co., Ltd.	+86-86-18148706580 +8618826483838	evan@tyvovo.com	China	153	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58

1051375-16-6(ドルテグラビル)キーワード:

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• 1051375-16-6
• Dolutegravir API
• 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-
• (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide Dolutegravir (GSK1349572)
• GSK1349572, S-349572, GSK572
• (4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
• Dolutegravir, >=98%
• Dolutegravir free acid
• GSK1349572
• (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
• S/GSK1349572 (GSK1349572)
• GSK1349572(dolutegravir)
• dolutegravir/GSK1349572/S-349572
• Dolutegravir (S/GSK1349572
• CS-9
• Dolutegravir - GSK 1349572 | Soltegravir | Tivicay
• BNKY001-DL04
• S/GSK1349572 (Dolutegravir)
• 134413
• Dolutegravir DTG
• (3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide
• Pharmaceutical ingredient against HIV GSK1349572
• GSK1349572 USP/EP/BP
• Dolutegravir (0.1 mg/mL in Methanol)
• Dolutegravir D3Q: What is Dolutegravir D3 Q: What is the CAS Number of Dolutegravir D3 Q: What is the storage condition of Dolutegravir D3 Q: What are the applications of Dolutegravir D3
• DolutegravirQ: What is Dolutegravir Q: What is the CAS Number of Dolutegravir Q: What is the storage condition of Dolutegravir Q: What are the applications of Dolutegravir
• Dolutegravir Tablet
• Dolutegravir (GSK1349572)
• Dolutegravi
• Dolutegravir
• S/GSK1349572
• ドルテグラビル
• GSK-1349572
• テビケイ
• (4R,12aS)-N-[(2,4-ジフルオロフェニル)メチル]-7-ヒドロキシ-4-メチル-6,8-ジオキソ-3,4,6,8,12,12a-ヘキサヒドロ-2H-ピリド[1′,2′:4,5]ピラジノ[2,1-b][1,3]オキサジン-9-カルボキサミド
• (3S,7R)-N-[(2,4-ジフルオロフェニル)メチル]-11-ヒドロキシ-7-メチル-9,12-ジオキソ-4-オキサ-1,8-ジアザトリシクロ[8.4.0.03,8]テトラデカ-10,13-ジエン-13-カルボキサミド
• (4R,9aS)-N-(2,4-ジフルオロベンジル)-5-ヒドロキシ-3,4,6,9,9a,10-ヘキサヒドロ-4-メチル-6,10-ジオキソ-2H-1-オキサ-4a,8a-ジアザアントラセン-7-カルボアミド
• (4R,9aS)-5-ヒドロキシ-3,4,9,9a-テトラヒドロ-7-[(2,4-ジフルオロベンジル)カルバモイル]-4-メチル-2H-1-オキサ-4a,8a-ジアザアントラセン-6,10-ジオン
• (4R,9aS)-N-(2,4-ジフルオロベンジル)-5-ヒドロキシ-4-メチル-6,10-ジオキソ-3,4,6,9,9a,10-ヘキサヒドロ-2H-1-オキサ-4a,8a-ジアザアントラセン-7-カルボアミド