デカメトニウムブロミド

デカメトニウムブロミド 価格 もっと(9)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01COBQE-6722	臭化デカメソニウム Decamethonium bromide	541-22-0	1g	￥20000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQE-6722	臭化デカメソニウム Decamethonium bromide	541-22-0	5g	￥60000	2024-03-01	購入
東京化成工業	D1314	デカメトニウムブロミド >98.0%(T) Decamethonium Bromide >98.0%(T)	541-22-0	5g	￥9000	2024-03-01	購入
東京化成工業	D1314	デカメトニウムブロミド >98.0%(T) Decamethonium Bromide >98.0%(T)	541-22-0	25g	￥23000	2024-03-01	購入
Sigma-Aldrich Japan	D1260	デカメトニウムブロミド crystalline Decamethonium bromide crystalline	541-22-0	5g	￥19900	2024-03-01	購入

デカメトニウムブロミド 化学特性,用途語,生産方法

外観

白色～わずかにうすい褐色、粉末又は塊

溶解性

水及びエタノールに溶ける。

用途

薬理・生理作用研究用、イオンペア試薬。

説明

Decamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC₅₀ value of 40 μM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC₅₀ values of 7.4, 405, 28, and 59 μM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC₅₀ = 52 μM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED₉₅ values of 35 and 70 μg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.

化学的特性

crystalline solid

使用

antipsychotic

生物学の機能

Decamethonium was one of the first neuromuscular blocking agents to be synthesized. An SAR study on a series of bis-quaternary ammonium compounds with varying numbers of methylene groups separating the nitrogen atoms demonstrated that maximal neuromuscular blockade occurred with 10 to 12 unsubstituted methylene groups. Activity diminished as the number of carbons was either decreased or increased. The compound with six methylene groups, hexamethonium, is a nicotinic antagonist at autonomic ganglia (ganglionic blocking agent). All the compounds in this series that possessed neuromuscular blocking activity also caused depolarization of the postjunctional membrane.

一般的な説明

Crystals derived from methanol and acetone.

空気と水の反応

Water soluble.

健康ハザード

ACUTE/CHRONIC HAZARDS: When heated to decomposition DECAMETHONIUM BROMIDE emits very toxic fumes.

火災危険

Flash point data for DECAMETHONIUM BROMIDE are not available. DECAMETHONIUM BROMIDE is probably combustible.

デカメトニウムブロミド 上流と下流の製品情報

原材料

準備製品

デカメトニウムブロミド 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	27894	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50002	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94838	76

541-22-0(デカメトニウムブロミド)キーワード:

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• 541-22-0
• 1,10-Decanediaminium,N,N,N,N’,N’,N’-hexamethyl-,dibromide
• 10-decanediaminium,n,n,n,n’,n’,n’-hexamethyl-dibromide
• decacuran
• decamethoniumdibromide
• decamethylene-1,10-bistrimethylammoniumdibromide
• decamethylenebis(trimethyl-ammoniudibromide
• 1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2)
• dekamethoniumbromid
• DECANE-1,10-BIS(TRIMETHYLAMMONIUM BROMIDE)
• DECAMETHONIUM BROMIDE
• DECAMETHYLENEBIS[TRIMETHYL-AMMONIUM BROMIDE]
• syncurine
• DECAMETHONIUM BROMIDE, FOR ION PAIR CHRO MATOGRAPHY
• 1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, monobromide
• Ammonium, decamethylenebis[trimethyl-, dibromide
• Decamethonium bromide ,98%
• N1,N1,N1,N10,N10,N10-hexaMethyldecane-1,10-diaMiniuM broMide
• Decamethylene bis(trimethylammonium bromide), Decane-1,10-bis(trimethylammonium bromide)
• Decamethonium Bromide >
• DECAMETHONIUM BROMIDE USP/EP/BP
• Decamethonium (Bromide)(Reagent for Ion-Pair Chromatography,99%)
• nAChR,Decamethonium bromide,inhibit,Inhibitor,Decamethonium,Nicotinic acetylcholine receptors
• Decamethonium Bromide, ≥ 98.0%
• デカメトニウムブロミド
• デカメトニウムジブロミド
• デカクラン
• N,N,N,N',N',N'-ヘキサメチル-1,10-デカンジアミニウム·ジブロミド
• デカン-1,10-ビス(トリメチルアンモニウムブロミド)
• デカメチレンビス(トリメチルアミニウム)·ジブロミド
• N,N,N,N',N',N'-ヘキサメチル-1,10-デカンジアミニウム·2ブロミド
• 臭化デカメトニウム
• デカメチレンビス(トリメチルアンモニウムブロミド)
• 臭化デカメソニウム
• 第四級アンモニウム化合物
• 構造分類
• アンモニウムブロミド (第四級)