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NDT9513727

NDT9513727 化学構造式
439571-48-9
CAS番号.
439571-48-9
化学名:
NDT9513727
别名:
NDT9513727
英語名:
NDT 9513727
英語别名:
NDT 9513727;N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine;1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-
CBNumber:
CB82603001
化学式:
C36H35N3O4
分子量:
573.68
MOL File:
439571-48-9.mol

NDT9513727 物理性質

沸点 :
723.1±62.0 °C(Predicted)
比重(密度) :
1.23±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO: 100 mM; Ethanol: 100 mM
外見 :
A solid
酸解離定数(Pka):
6.69±0.50(Predicted)

安全性情報

NDT9513727 価格 もっと(5)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC3333
NDT 9513727 		439571-48-9 10mg ￥97000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC3333
NDT 9513727 		439571-48-9 50mg ￥411000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCN385500 NDT9513727
NDT 9513727 		439571-48-9 10mg ￥66600 2023-06-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCN385500 NDT9513727
NDT 9513727 		439571-48-9 50mg ￥308000 2023-06-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCN385500 NDT9513727
NDT 9513727 		439571-48-9 100mg ￥517800 2023-06-01 購入

NDT9513727 化学特性,用途語,生産方法

説明

NDT 9513727 is a competitive antagonist of the C5a receptor (C5aR; IC50 = 11.6 nM for human recombinant receptors) that has inverse agonist activity in a GTPγ[35S] assay. It is selective for human recombinant over rat and mouse recombinant C5aRs (IC50 = >10 μM for both) but does have activity at macaque and gerbil receptors (IC50s = 7.3 and 6.4 nM, respectively). NDT 9513727 inhibits degranulation in U937 cells stimulated with C5a (IC50 = 7.1 nM). It also prevents neutropenia induced by human recombinant C5a in gerbils (ED50 = 2.2 mg/kg) and in cynomolgus macaques when administered at doses of 5 and 25 mg/kg.

使用

NDT 9513727 is a selective, and potent inverse agonist of the human C5aR. NDT 9513727 has been shown to effectively inhibit C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo. These results suggest that NDT 9513727 is a promising candidate for the treatment of human inflammatory diseases.

NDT9513727 上流と下流の製品情報

原材料

準備製品

NDT9513727 生産企業

Global( 36)Suppliers
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  • 439571-48-9
  • NDT 9513727
  • N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine
  • 1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-
  • NDT9513727
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