Balofloxacin manufacturers and suppliers

Balofloxacin suppliers

Properties

Melting point:: 137°C

Boiling point:: 608.3±55.0 °C(Predicted)

Density: 1.40±0.1 g/cm3(Predicted)

storage temp.: Keep in dark place,Inert atmosphere,2-8°C

solubility: H2O : < 0.1 mg/mL (insoluble)DMSO : 0.67 mg/mL (1.72 mM; Need ultrasonic)

pka: 6.44±0.50(Predicted)

BRN: 8362117

Safety Information

Symbol(GHS): GHS02

Signal word: Warning

Hazard statements: H228

Precautionary statements: P403-P501c

WGK Germany: 3

Use

Balofloxacin, a novel orally-active fluoroquinolone antibiotic, was introduced in South Korea for the treatment of urinary tract infections (UTI). It can be synthetized by reaction of 3-(methylamino)piperidine with the classical 4-quinolone-3-carboxylic acid template. In vitro antibacterial activity of balofloxacin against gram-positive bacteria (Staphylococcus aureus including methicillin-resistant S. aureus, Staphylococcus epidermis, Streptococcus pneumonia, Streptococcus pyrogenes) was almost equal to that of sparfloxacin or tosufloxacin, in contrast its activity against gram-negative bacteria was 2 times or more lower. In clinical trials, balofloxacin was well tolerated and showed comparable efficacy to ofloxacin in patients with UTls. After oral administration, balofloxacin was well absorbed, and was primarily eliminated unchanged in the urine with an elimination half-life of approximately 8 h. In animal studies, balofloxacin did not exhibit any phototoxicity.

You can find Balofloxacin suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.