Lonidamine manufacturers and suppliers

Lonidamine suppliers

Properties

Melting point:: 207-209°C

Boiling point:: 537.9±45.0 °C(Predicted)

Density: 1.4835 (rough estimate)

refractive index: 1.6070 (estimate)

storage temp.: Sealed in dry,2-8°C

solubility: Soluble in DMSO (up to 25 mg/ml).

form: solid

pka: 3.00±0.10(Predicted)

color: White

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

InChIKey: WDRYRZXSPDWGEB-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H302-H351-H360

Precautionary statements: P201-P301+P312+P330-P308+P313

Hazard Codes: T

Risk Statements: 60-22-40

Safety Statements: 53-22-36/37/39-45

WGK Germany: 3

RTECS: NK7886000

HS Code: 29339900

Toxicity: LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood)

Use

Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH).

You can find Lonidamine suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.