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ChemicalBook >> CAS DataBase List >> (4R)-4-benzyl-2-(3H-imidazol-4-ylmethyl)-5-thiophen-2-ylsulfonyl-2,5-diazabicyclo[5.4.0]undeca-8,10,12-triene-9-carbonitrile

(4R)-4-benzyl-2-(3H-imidazol-4-ylmethyl)-5-thiophen-2-ylsulfonyl-2,5-diazabicyclo[5.4.0]undeca-8,10,12-triene-9-carbonitrile

(4R)-4-benzyl-2-(3H-imidazol-4-ylmethyl)-5-thiophen-2-ylsulfonyl-2,5-diazabicyclo[5.4.0]undeca-8,10,12-triene-9-carbonitrile price.
  • $180 - $5486.25
  • Product name: (4R)-4-benzyl-2-(3H-imidazol-4-ylmethyl)-5-thiophen-2-ylsulfonyl-2,5-diazabicyclo[5.4.0]undeca-8,10,12-triene-9-carbonitrile
  • CAS: 195987-41-8
  • MF: C25H23N5O2S2
  • MW: 489.61
  • EINECS:
  • MDL Number:MFCD09955166
  • Synonyms:(4R)-4-benzyl-2-(3H-imidazol-4-ylmethyl)-5-thiophen-2-ylsulfonyl-2,5-diazabicyclo[5.4.0]undeca-8,10,12-triene-9-carbonitrile;1H-1,4-Benzodiazepine-7-carbonitrile,2,3,4,5-tetrahydro-1-(1H-iMidazol-5-ylMethyl)-3-(phenylMethyl)-4-(2-thienylsulfonyl)-,(3R)-;(3R)-2,3,4,5-Tetrahydro-1-(1H-iMidazol-4-ylMethyl)-3-(phenylMethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile;(R)-2,3,4,5-Tetrahydro-1-(1H-iMidazol-4-ylMethyl)-3-(phenylMethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-ca;BMS214662; BMS 214662;7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine;(3R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-5-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile
Price12 Properties Safety Information Description
12 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100MG
  • ManufacturerAK Scientific
  • Product number3060CC
  • Product descriptionBms-214662
  • Packaging1mg
  • Price$538
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008109
  • Product descriptionBMS-214662 95.00%
  • Packaging100MG
  • Price$5486.25
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number28713
  • Product descriptionBMS 214662
  • Packaging1mg
  • Price$396
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6471
  • Product descriptionBMS-214662 99.59%
  • Packaging1mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6471
  • Product descriptionBMS-214662 99.59%
  • Packaging5mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6471
  • Product descriptionBMS-214662 99.59%
  • Packaging10mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6471
  • Product descriptionBMS-214662 99.59%
  • Packaging25mg
  • Price$1440
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6471
  • Product descriptionBMS-214662 99.59%
  • Packaging50mg
  • Price$2340
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6471
  • Product descriptionBMS-214662 99.59%
  • Packaging100mg
  • Price$4080
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10200
  • Product descriptionBMS-214662 >98%
  • Packaging100mg
  • Price$1500
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number49919
  • Product descriptionBMS214662
  • Packaging1mg
  • Price$675
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberB596050
  • Product descriptionBMS214662
  • Packaging10mg
  • Price$1240
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3060CC Bms-214662 1mg $538 2021-12-16 Buy
American Custom Chemicals Corporation API0008109 BMS-214662 95.00% 100MG $5486.25 2021-12-16 Buy
Cayman Chemical 28713 BMS 214662 1mg $396 2024-03-01 Buy
ChemScene CS-6471 BMS-214662 99.59% 1mg $180 2021-12-16 Buy
ChemScene CS-6471 BMS-214662 99.59% 5mg $420 2021-12-16 Buy
ChemScene CS-6471 BMS-214662 99.59% 10mg $720 2021-12-16 Buy
ChemScene CS-6471 BMS-214662 99.59% 25mg $1440 2021-12-16 Buy
ChemScene CS-6471 BMS-214662 99.59% 50mg $2340 2021-12-16 Buy
ChemScene CS-6471 BMS-214662 99.59% 100mg $4080 2021-12-16 Buy
DC Chemicals DC10200 BMS-214662 >98% 100mg $1500 2021-12-16 Buy
Medical Isotopes, Inc. 49919 BMS214662 1mg $675 2021-12-16 Buy
TRC B596050 BMS214662 10mg $1240 2021-12-16 Buy

Properties

Boiling point :790.9±70.0 °C(Predicted)
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: slightly soluble; Methanol: slightly soluble
form :A solid
pka :13.19±0.10(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

BMS 214662 is a potent inhibitor of farnesyltransferase (FTase; IC50 = 1.3 nM). It is selective for FTase over geranylgeranyl transferase (GGTase; IC50 = 1,900 nM). It inhibits the growth of MEK2, A2780, and PC3 cancer cells expressing wild-type Ras (IC50s = 2.5, 0.04, and 0.15 μM, respectively), as well as HCT116, MIP, RC-165, and MIA PaCa-2 cells expressing mutant K-Ras (IC50s = 0.06, 0.3, 0.3, and 0.12 μM, respectively). BMS 214662 induces apoptosis in HCT116 cells in a concentration-dependent manner. In vivo, BMS 214662 (600 mg/kg) is curative in an HCT116 mouse xenograft model. It also reduces tumor growth in Calu-1, HT-29, EJ-1, and MIA PaCa-2 mouse xenograft models.

Suppliers and manufacturers

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