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ChemicalBook >> CAS DataBase List >> 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE price.
  • $121 - $1400
  • Product name: 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE
  • CAS: 566-76-7
  • MF: C18H22O3
  • MW: 286.37
  • EINECS:
  • MDL Number:MFCD00870436
  • Synonyms:1,3,5(10)-ESTRATRIEN-3,16-ALPHA-DIOL-17-ONE;3,16ALPHA-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE;(16R)-3,16α-Dihydroxy-1,3,5(10)-estratriene-17-one;16α-OHE1;3,16α-Dihydroxy-1,3,5(10)-estratrien-17-one;C05300;(16α)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one;Estra-1,3,5(10)-triene-3,16α-diol-17-one
11 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • IsoSciences
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 1mL(100ug/mL)
  • 1MG
  • 2.5MG
  • 5mg
  • 10mg
  • 25MG
  • 1ML
  • ManufacturerAK Scientific
  • Product numberZ1964
  • Product description16-HydroxyEstrone
  • Packaging10mg
  • Price$835
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberSHG0007053
  • Product description1,3,5[10]-ESTRATRIENE-3,16-ALPHA-DIOL-17-ONE 95.00%
  • Packaging1MG
  • Price$485
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberSHG0007053
  • Product description1,3,5[10]-ESTRATRIENE-3,16-ALPHA-DIOL-17-ONE 95.00%
  • Packaging2.5MG
  • Price$525
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberSHG0007053
  • Product description1,3,5[10]-ESTRATRIENE-3,16-ALPHA-DIOL-17-ONE 95.00%
  • Packaging25MG
  • Price$1400
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15208
  • Product description16α-hydroxy Estrone ≥98%
  • Packaging1mg
  • Price$121
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15208
  • Product description16α-hydroxy Estrone ≥98%
  • Packaging5mg
  • Price$423
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15208
  • Product description16α-hydroxy Estrone ≥98%
  • Packaging10mg
  • Price$662
  • Updated2024-03-01
  • Buy
  • ManufacturerIsoSciences
  • Product numberS10156UNL
  • Product description16α-Hydroxyestrone(Solution) ≥98%
  • Packaging1mL(100ug/mL)
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number10793
  • Product description16α-Hydroxyestrone
  • Packaging10mg
  • Price$390
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberH-126
  • Product description16α-Hydroxyestrone 100?μg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant?
  • Packaging1ML
  • Price$462
  • Updated2022-05-15
  • Buy
  • ManufacturerTRC
  • Product numberH941900
  • Product description16α-HydroxyEstrone
  • Packaging10mg
  • Price$550
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Z1964 16-HydroxyEstrone 10mg $835 2021-12-16 Buy
American Custom Chemicals Corporation SHG0007053 1,3,5[10]-ESTRATRIENE-3,16-ALPHA-DIOL-17-ONE 95.00% 1MG $485 2021-12-16 Buy
American Custom Chemicals Corporation SHG0007053 1,3,5[10]-ESTRATRIENE-3,16-ALPHA-DIOL-17-ONE 95.00% 2.5MG $525 2021-12-16 Buy
American Custom Chemicals Corporation SHG0007053 1,3,5[10]-ESTRATRIENE-3,16-ALPHA-DIOL-17-ONE 95.00% 25MG $1400 2021-12-16 Buy
Cayman Chemical 15208 16α-hydroxy Estrone ≥98% 1mg $121 2024-03-01 Buy
Cayman Chemical 15208 16α-hydroxy Estrone ≥98% 5mg $423 2024-03-01 Buy
Cayman Chemical 15208 16α-hydroxy Estrone ≥98% 10mg $662 2024-03-01 Buy
IsoSciences S10156UNL 16α-Hydroxyestrone(Solution) ≥98% 1mL(100ug/mL) $380 2021-12-16 Buy
Medical Isotopes, Inc. 10793 16α-Hydroxyestrone 10mg $390 2021-12-16 Buy
Sigma-Aldrich H-126 16α-Hydroxyestrone 100?μg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant? 1ML $462 2022-05-15 Buy
TRC H941900 16α-HydroxyEstrone 10mg $550 2021-12-16 Buy

Properties

Melting point :209-211°C
Boiling point :493.2±45.0 °C(Predicted)
Density :1.249±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form :Solid
pka :10.23±0.60(Predicted)
color :White to Light Beige

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.

Description

The naturally-occurring estrogens are estrone (E1, ), estradiol (E2, ), and estriol (E3, ). 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE1 is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E1, 16α-OHE1 binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE1 are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive.

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