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ChemicalBook >> CAS DataBase List >> A-443654

A-443654

A-443654 price.
  • $68 - $793.9
  • Product name: A-443654
  • CAS: 552325-16-3
  • MF: C24H23N5O
  • MW: 397.47
  • EINECS:
  • MDL Number:MFCD11840663
  • Synonyms:A-443654;1H-Indole-3-ethanaMine, a-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]Methyl]-, (aS)-;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-(S)-1H-indole-3-ethanamine;A-443654;A443654;(2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine;1H-Indole-3-ethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-;inhibit,A443654,A-443654,Inhibitor,PKB,Akt,A 443654,Protein kinase B
15 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 5mg
  • 10mg
  • 10mM(in 1mL DMSO)
  • 500μg
  • 1MG
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3663-M005
  • Product descriptionA-443654 ≥98%
  • Packaging5mg
  • Price$340
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001420
  • Product descriptionA-443654 95.00%
  • Packaging1MG
  • Price$305.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001420
  • Product descriptionA-443654 95.00%
  • Packaging5MG
  • Price$503.87
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3135
  • Product descriptionA-443654
  • Packaging1mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3135
  • Product descriptionA-443654
  • Packaging10mM(in 1mL DMSO)
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3135
  • Product descriptionA-443654
  • Packaging5mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611401
  • Product descriptionA-443654
  • Packaging5mg
  • Price$569.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611401
  • Product descriptionA-443654
  • Packaging10mg
  • Price$793.9
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16499
  • Product descriptionA-443654 ≥98%
  • Packaging500μg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16499
  • Product descriptionA-443654 ≥98%
  • Packaging1mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16499
  • Product descriptionA-443654 ≥98%
  • Packaging5mg
  • Price$401
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0405
  • Product descriptionA-443654 99.04%
  • Packaging1mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0405
  • Product descriptionA-443654 99.04%
  • Packaging5mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0405
  • Product descriptionA-443654 99.04%
  • Packaging10mg
  • Price$590
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC22498
  • Product descriptionA-443654 >98%
  • Packaging5mg
  • Price$280
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3663-M005 A-443654 ≥98% 5mg $340 2021-12-16 Buy
American Custom Chemicals Corporation INB0001420 A-443654 95.00% 1MG $305.55 2021-12-16 Buy
American Custom Chemicals Corporation INB0001420 A-443654 95.00% 5MG $503.87 2021-12-16 Buy
ApexBio Technology A3135 A-443654 1mg $120 2021-12-16 Buy
ApexBio Technology A3135 A-443654 10mM(in 1mL DMSO) $315 2021-12-16 Buy
ApexBio Technology A3135 A-443654 5mg $360 2021-12-16 Buy
Biorbyt Ltd orb611401 A-443654 5mg $569.5 2021-12-16 Buy
Biorbyt Ltd orb611401 A-443654 10mg $793.9 2021-12-16 Buy
Cayman Chemical 16499 A-443654 ≥98% 500μg $68 2024-03-01 Buy
Cayman Chemical 16499 A-443654 ≥98% 1mg $109 2024-03-01 Buy
Cayman Chemical 16499 A-443654 ≥98% 5mg $401 2024-03-01 Buy
ChemScene CS-0405 A-443654 99.04% 1mg $110 2021-12-16 Buy
ChemScene CS-0405 A-443654 99.04% 5mg $330 2021-12-16 Buy
ChemScene CS-0405 A-443654 99.04% 10mg $590 2021-12-16 Buy
DC Chemicals DC22498 A-443654 >98% 5mg $280 2021-12-16 Buy

Properties

Boiling point :722℃
Density :1.307
Flash point :390℃
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥19.85 mg/mL in DMSO; ≥44.3 mg/mL in EtOH
form :solid
pka :13.43±0.40(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBα, β, γ) modulate cell proliferation, metabolism, and survival as well as angiogenesis. A-443654 is an inhibitor of Akt (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation. It induces G2/M accumulation, defects in centrosome separation, and formation of either monopolar arrays or disorganized spindles. A-443654 has been reported to slow the progression of Akt-dependent tumors in in vivo mouse models. In response to an A-443654-induced decrease in phosphorylation of Akt targets, a concomitant increase in Thr308 and Ser473 phosphorylation of Akt has been observed in human cancer cell lines. A-443654 has been used to examine the mechanism of this rapid feedback reaction.