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ChemicalBook >> CAS DataBase List >> DESMETHYL SILDENAFIL

DESMETHYL SILDENAFIL

DESMETHYL SILDENAFIL price.
  • $36 - $1593.9
  • Product name: DESMETHYL SILDENAFIL
  • CAS: 139755-82-1
  • MF: C21H28N6O4S
  • MW: 460.55
  • EINECS:
  • MDL Number:MFCD00908398
  • Synonyms:DESMETHYL SILDENAFIL;5-[2-Ethoxy-5-(1-piperazinylsulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propyl- 7H-pyrazolo[4,3-d]pyrimidin-7-one;UK 103320;Sildenafil N-DesMethyl IMpurity;5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one;Sildenafil N-desmethyl;Sildenafil N-desmethy impurity;Sildenafil EP Impurity F (Sildenafil N-Desmethyl Metabolite)
Price29 Properties Safety Information Description
29 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chemtos
  • Crysdot
  • Medical Isotopes, Inc.
  • TRC
Package
  • 1mg
  • 2mg
  • 5MG
  • 10mg
  • 25mg
  • 50MG
  • 100mg
  • 250mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAK Scientific
  • Product numberJ11755
  • Product descriptionSildenafilEPImpurityF(N-DesmethylSildenafil)
  • Packaging25mg
  • Price$94
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY0500
  • Product descriptionN-Desmethylsildenafil
  • Packaging5g
  • Price$721
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ11755
  • Product descriptionSildenafilEPImpurityF(N-DesmethylSildenafil)
  • Packaging1g
  • Price$894
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ55575
  • Product descriptionN-Desmethylsildenafil
  • Packaging10g
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156415
  • Product description5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95%
  • Packaging250mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156415
  • Product description5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95%
  • Packaging1g
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156415
  • Product description5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95%
  • Packaging5g
  • Price$324
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0046132
  • Product descriptionSILDENAFIL PIPERAZINE IMPURITY 95.00%
  • Packaging5MG
  • Price$457.51
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberMTB0000257
  • Product descriptionN-DESMETHYL SILDENAFIL 95.00%
  • Packaging5MG
  • Price$738.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberMTB0000257
  • Product descriptionN-DESMETHYL SILDENAFIL 95.00%
  • Packaging50MG
  • Price$1593.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging2mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging5mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging10mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging25mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD21324
  • Product descriptionN-Desmethyl sildenafil
  • Packaging50mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18208
  • Product descriptionN-Desmethyl Sildenafil ≥98%
  • Packaging1mg
  • Price$36
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J11755 SildenafilEPImpurityF(N-DesmethylSildenafil) 25mg $94 2021-12-16 Buy
AK Scientific Y0500 N-Desmethylsildenafil 5g $721 2021-12-16 Buy
AK Scientific J11755 SildenafilEPImpurityF(N-DesmethylSildenafil) 1g $894 2021-12-16 Buy
AK Scientific J55575 N-Desmethylsildenafil 10g $900 2021-12-16 Buy
Ambeed A156415 5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95% 250mg $44 2021-12-16 Buy
Ambeed A156415 5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95% 1g $115 2021-12-16 Buy
Ambeed A156415 5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 95% 5g $324 2021-12-16 Buy
American Custom Chemicals Corporation API0046132 SILDENAFIL PIPERAZINE IMPURITY 95.00% 5MG $457.51 2021-12-16 Buy
American Custom Chemicals Corporation MTB0000257 N-DESMETHYL SILDENAFIL 95.00% 5MG $738.1 2021-12-16 Buy
American Custom Chemicals Corporation MTB0000257 N-DESMETHYL SILDENAFIL 95.00% 50MG $1593.9 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 2mg $104 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 5mg $200 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 10mg $320 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 25mg $600 2021-12-16 Buy
Biosynth Carbosynth FD21324 N-Desmethyl sildenafil 50mg $750 2021-12-16 Buy
Cayman Chemical 18208 N-Desmethyl Sildenafil ≥98% 1mg $36 2024-03-01 Buy
Next Last

Properties

Melting point :158-160°C
Density :1.44±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml
form :A crystalline solid
pka :10.05±0.20(Predicted)
Stability :Moisture Sensitive

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Sildenafil is a potent cGMP-specific phosphodiesterase (PDE) inhibitor that is highly selective for PDE5 (IC50 = 3.6 nM). Inhibition of PDE5 prolongs nitric oxide-mediated relaxation of smooth muscle in a range of vascular tissues. N-Desmethyl sildenafil is a major metabolite of sildenafil. The conversion of sildenafil to this metabolite is affected by age and by renal and hepatic impairment.

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Suppliers and manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
N-Desmethyl Sildenafil
$1.20 /1KG
N-Desmethyl Sildenafil CAS:139755-82-1
Hubei Jusheng Technology Co.,Ltd.
Standardpharm Co. Ltd.
Career Henan Chemica Co
sgtlifesciences pvt ltd
LEAP CHEM CO., LTD.
China National Standard Pharmaceutical Corporation Limited
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
Amadis Chemical Company Limited