DO264
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- $73 - $2400
- Product name: DO264
- CAS: 2301866-59-9
- MF: C23H20Cl2F3N5O2S
- MW: 558.4
- EINECS:604-604-1
- MDL Number:MFCD31812603
- Synonyms:N-[1-[3-Chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinylthiourea;Thiourea, N-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinyl-;DO264;DO-264;DO 264;DO264 (DO-264;DO264
10 prices
Selected condition：
Brand
- AK Scientific
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 1g
- ManufacturerAK Scientific
- Product number8011EL
- Product descriptionCID134813646
- Packaging1mg
- Price$179
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2982
- Product descriptionDO264 99%
- Packaging25mg
- Price$511.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBD167529
- Product descriptionDO 264
- Packaging10mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBD167529
- Product descriptionDO 264
- Packaging50mg
- Price$472.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29402
- Product descriptionDO264
- Packaging1mg
- Price$73
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29402
- Product descriptionDO264
- Packaging5mg
- Price$324
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29402
- Product descriptionDO264
- Packaging10mg
- Price$575
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0077182
- Product descriptionDO-264 98.81%
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0077182
- Product descriptionDO-264 98.81%
- Packaging10mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC11464
- Product descriptionDO-264 >98%
- Packaging1g
- Price$2400
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8011EL | CID134813646 | 1mg | $179 | 2021-12-16 | Buy |
| Axon Medchem | Axon2982 | DO264 99% | 25mg | $511.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BD167529 | DO 264 | 10mg | $135 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BD167529 | DO 264 | 50mg | $472.5 | 2021-12-16 | Buy |
| Cayman Chemical | 29402 | DO264 | 1mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 29402 | DO264 | 5mg | $324 | 2024-03-01 | Buy |
| Cayman Chemical | 29402 | DO264 | 10mg | $575 | 2024-03-01 | Buy |
| ChemScene | CS-0077182 | DO-264 98.81% | 5mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0077182 | DO-264 98.81% | 10mg | $250 | 2021-12-16 | Buy |
| DC Chemicals | DC11464 | DO-264 >98% | 1g | $2400 | 2021-12-16 | Buy |
Properties
Boiling point :601.5±65.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml).
form :solid
pka :11.53±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml).
form :solid
pka :11.53±0.70(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
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Description
DO264 is an inhibitor of α/β-hydrolase domain-containing protein 12 (ABHD12; IC50 = 11 nM). It inhibits ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells. DO264 increases levels of chemokine (C-C motif) ligand 3 (CCL3), CCL4, TNF-α, and IL-1β in M1-polarized THP-1 macrophages. It potentiates ferroptotic cell death induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in HT1080 fibrosarcoma and SU-DHL-5 B cell lymphoma cells when used at a concentration of 1 μM. In vivo, DO264 (30 mg/kg per day for four weeks) increases levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PS, 1-arachidonoyl-2-hydroxy-sn-glycero-3-PS, 1-docosanoyl-2-hydroxy-sn-glycero-3-PS, 1-stearoyl-2-arachidonoyl-sn-glycero-3-PS, and 1-oleoyl-2-arachidonoyl-sn-glycero-3-PS in mouse brain. It increases levels of CCL2, CCL3, and CCL5 in bronchoalveolar lavage fluid (BALF) and decreases survival in a mouse model of infection with lymphocytic choriomeningitis virus (LCMV) clone 13 when administered at a dose of 30 mg/kg.Related product price
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