TAK-960
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- $62 - $11900
- Product name: TAK-960
- CAS: 1137868-52-0
- MF: C27H34F3N7O3
- MW: 561.6
- EINECS:
- MDL Number:MFCD22420821
- Synonyms:TAK-960;4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide;4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide;CS-1725;TAK 960;TAK960;CS-554;Benzamide, 4-[(9-cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)-;Polo-like Kinase (PLK),cell,cancer,proliferation,Inhibitor,mitosis,TAK960,TAK 960,leukemia,inhibit,phosphorylation,lines,TAK-960
25 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 5MG
- 10mg
- 10mM(in 1mL DMSO)
- 50mg
- 100mg
- 250mg
- 1G
- 1000mg
- ManufacturerAK Scientific
- Product number2743AH
- Product descriptionTAK-960
- Packaging50mg
- Price$378
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0017272
- Product descriptionTAK-960 95.00%
- Packaging5MG
- Price$457.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0017272
- Product descriptionTAK-960 95.00%
- Packaging1G
- Price$11900
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5860
- Product descriptionTAK960
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5860
- Product descriptionTAK960
- Packaging10mM(in 1mL DMSO)
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5860
- Product descriptionTAK960
- Packaging10mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5860
- Product descriptionTAK960
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181158
- Product descriptionTAK-960 >99.8%
- Packaging100mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181158
- Product descriptionTAK-960 >99.8%
- Packaging250mg
- Price$1654.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181158
- Product descriptionTAK-960 >99.8%
- Packaging1000mg
- Price$3432.3
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT104283
- Product descriptionTAK 960
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFT104283
- Product descriptionTAK 960
- Packaging50mg
- Price$647.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17701
- Product descriptionTAK-960 ≥95%
- Packaging1mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17701
- Product descriptionTAK-960 ≥95%
- Packaging5mg
- Price$270
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17701
- Product descriptionTAK-960 ≥95%
- Packaging10mg
- Price$419
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17701
- Product descriptionTAK-960 ≥95%
- Packaging50mg
- Price$1189
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2743AH | TAK-960 | 50mg | $378 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0017272 | TAK-960 95.00% | 5MG | $457.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0017272 | TAK-960 95.00% | 1G | $11900 | 2021-12-16 | Buy |
| ApexBio Technology | B5860 | TAK960 | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | B5860 | TAK960 | 10mM(in 1mL DMSO) | $160 | 2021-12-16 | Buy |
| ApexBio Technology | B5860 | TAK960 | 10mg | $175 | 2021-12-16 | Buy |
| ApexBio Technology | B5860 | TAK960 | 50mg | $540 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181158 | TAK-960 >99.8% | 100mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181158 | TAK-960 >99.8% | 250mg | $1654.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181158 | TAK-960 >99.8% | 1000mg | $3432.3 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT104283 | TAK 960 | 10mg | $185 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT104283 | TAK 960 | 50mg | $647.5 | 2021-12-16 | Buy |
| Cayman Chemical | 17701 | TAK-960 ≥95% | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 17701 | TAK-960 ≥95% | 5mg | $270 | 2024-03-01 | Buy |
| Cayman Chemical | 17701 | TAK-960 ≥95% | 10mg | $419 | 2024-03-01 | Buy |
| Cayman Chemical | 17701 | TAK-960 ≥95% | 50mg | $1189 | 2024-03-01 | Buy |
Properties
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥28.05 mg/mL in DMSO; insoluble in H2O; ≥12.3 mg/mL in EtOH
form :solid
pka :13.21±0.20(Predicted)
storage temp. :Store at -20°C
solubility :≥28.05 mg/mL in DMSO; insoluble in H2O; ≥12.3 mg/mL in EtOH
form :solid
pka :13.21±0.20(Predicted)
Safety Information
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| Signal word: | Danger | |||||||
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Description
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively. It exhibits greater than 20-fold selectivity for Plk1 over FAK, MLCK, and the tyrosine protein kinase Fes, and has minimal activity against a panel of 282 other kinases. It inhibits the proliferation of various cancer cell lines, including MDR1-expressing tumors, and also prevents tumor growth in several human cancer cell xenograft models, including a disseminated model of AML- and MDR1-expressing hematological tumors.Related product price
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