| | 221877-54-9 Basic information More.. |
| Product Name: | ZOTAROLIMUS | | Synonyms: | ZOTAROLIMUS;(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin;A 179578;ABT 578;Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-;Unii-H4gxr80ize;ZotaroliMus, >90%;42-(1-Tetrazolyl)rapamycin | | CAS: | 221877-54-9 | | MF: | C52H79N5O12 | | MW: | 966.21 | | EINECS: | | | Mol File: | 221877-54-9.mol |  |
Use
Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to mTOR preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.
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221877-54-9
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