| | 5370-01-4 Basic information More.. |
| Product Name: | Mexiletine hydrochloride | | Synonyms: | 1-(2,6-dimethylphenoxy)-2-aminopropanehydrochloride;1-(2,6-dimethylphenoxy)-2-propanaminhydrochloride;Ko 1173Cl;Mexilitene;1-(2,6-DIMETHYLPHENOXY)-2-PROPANANMINE HYDROCHLORIDE;MEXILETIN HYDROCHLORIDE;2-Propanamine, 1-(2,6-dimethylphenoxy)-, hydrochloride (9CI);Ethylamine, 1-methyl-2-(2,6-xylyloxy)-, hydrochloride (7CI, 8CI) | | CAS: | 5370-01-4 | | MF: | C11H18ClNO | | MW: | 215.72 | | EINECS: | 226-362-1 | | Mol File: | 5370-01-4.mol |  |
Use
Mexiletine hydrochloride, like class I antiarrhythmicagents, blocks the fast Na channel in cardiac cells. It isespecially effective on the Purkinje fibers in the heart. Thedrug increases the threshold of excitability of myocardialcells by reducing the rate of rise and amplitude of the actionpotential and decreases automaticity.Mexiletine hydrochloride is used for long-term oral prophylaxisof ventricular tachycardia. The drug is given in200- to 400-mg doses every 8 hours.
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5370-01-4
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