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Product Name:LL-Z-1640-2
Synonyms:(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione;(5Z)-7-Oxozeaenol;JNK/p38 inhibitor;C292, L 783278;LL-Z-1640-2;(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol);5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
CAS:66018-38-0
MF:C19H22O7
MW:362.37
EINECS:
Mol File:66018-38-0.mol
66018-38-0

Use

LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.

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Products Intro: Product Name:(5Z)-7-Oxozeaenol;(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-Methoxy-3-Methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
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