| | 152658-17-8 Basic information More.. |
| Product Name: | Nalfurafine | | Synonyms: | 17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride;TRK-820 HYDROCHLORIDE;(E)-N-((4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)-3-(furan-3-yl)-N-methylacrylamide;2-Propenamide, N-[(5a,6b)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-,hydrochloride (1:1), (2E)-;Nafurarphine Hydrochloride;Nalfurafina;AC 820;AC820 | | CAS: | 152658-17-8 | | MF: | C28H33ClN2O5 | | MW: | 513.02502 | | EINECS: | 200-258-5 | | Mol File: | 152658-17-8.mol |  |
Use
Nalfurafine hydrochloride was launched on March of 2009 in Japan as the first in class non-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test.
A new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.
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152658-17-8
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