| | 93908-02-2 Basic information More.. |
| Product Name: | REBECCAMYCIN | | Synonyms: | 5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione,1,11-dichloro-12,13-dihy;dro-12-(4-o-methyl-beta-d-glucopyranosyl)-;REBECCAMYCIN;REBECCAMYCIN, SACCHAROTHRIX AEROCOLONIGENES;1,11-Dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione;NSC 359079;7,10-Dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione;5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)- | | CAS: | 93908-02-2 | | MF: | C27H21Cl2N3O7 | | MW: | 570.38 | | EINECS: | | | Mol File: | 93908-02-2.mol |  |
Use
Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumor activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebeccamycin have been tested in clinical trials for cancer therapy.
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93908-02-2
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