| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
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Product Name:Umbelliprenin
CAS:532-16-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Cayman Chemical Company
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(800) 364-9897 |
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cayman@caymanchem.com |
| Products Intro: |
Product Name:Umbelliprenin
CAS:532-16-1
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| | 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one Basic information |
| Product Name: | 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one | | Synonyms: | 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one;(E,E)-7-((3,7,11-Trimethyl-2,6,10-dodecatrienyl)oxy)-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 7-[(3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)oxy]- | | CAS: | 532-16-1 | | MF: | C24H30O3 | | MW: | 366.49 | | EINECS: | | | Product Categories: | | | Mol File: | 532-16-1.mol | ![7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one Structure](CAS/GIF/532-16-1.gif) |
| | 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 30 mg/ml,DMSO: 5 mg/ml | | form | A crystalline solid |
| | 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one Usage And Synthesis |
| Definition | ChEBI: Umbelliprenin is a terpene lactone. | | Biological Activity | Umbelliprenin is a prenylated coumarin that has been found in Ferula and has diverse biological activities.1,2 It inhibits 5-lipoxygenase (5-LO) in a cell-free assay (IC50 = 72.5 nM).1 Umbelliprenin is active against L. major promastigotes (IC50 = 13.3 μM) and lethal to A. albopictus fourth instar larvae (LC50 = 194.96 ppm). It induces cell cycle arrest at the G1 phase in, as well as inhibits the growth of (IC50 = 12.5 μM), M4Beu metastatic pigmented melanoma cells and reduces tumor volume in a mouse Lewis lung carcinoma model. It reduces tumor growth and the number of metastases in a 4T1 mouse allograft model.2 Umbelliprenin (0.01 mmol/kg) reduces carrageenan-induced paw edema in mice.1 | | References | 1.Shakeri, A., Iranshahy, M., and Iranshahi, M.Biological properties and molecular targets of umbelliprenin--a mini-reviewJ. Asian Nat. Prod. Res.16(8)884-889(2014)
2.Rashidi, M., Khalilnezhad, A., Amani, D., et al.Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti-inflammatory, and immunostimulatory activities in 4T1 tumor-bearing Balb/c miceJ. Cell. Physiol.233(11)8908-8918(2018) |
| | 7-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]chromen-2-one Preparation Products And Raw materials |
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