| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:ARM-1
CAS:68729-05-5
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
Block Chemical Technology (Shanghai) Co., LTD
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| Tel: |
021-20432219 13918097649 |
| Email: |
li_jinfei@acblock-lab.com |
| Products Intro: |
Product Name:4-(4-Benzylphenyl)-1,3-thiazol-2-amine
CAS:68729-05-5
Purity:0.95 Package:5g,250g,1kg Remarks:24.8016
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| Product Name: | ARM1 | | Synonyms: | ARM1;4-(4-Benzylphenyl)-1,3-thiazol-2-amine;ARM-1
(ARM1);2-Thiazolamine, 4-[4-(phenylmethyl)phenyl]-;Epoxide Hydrolase,ARM1,HCT-116 cells,Inhibitor,LTA4H,ARM-1,cytotoxic,positive control,Aminopeptidase,4BSA,inhibit,ARM 1 | | CAS: | 68729-05-5 | | MF: | C16H14N2S | | MW: | 266.36 | | EINECS: | | | Product Categories: | | | Mol File: | 68729-05-5.mol |  |
| storage temp. | Store at -20°C | | solubility | ≤1mg/ml in ethanol;10mg/ml in DMSO;15mg/ml in dimethyl formamide | | form | crystalline solid |
| Description | Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 μM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 μM). ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase. | | Uses | Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 μM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 μM). ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.[Cayman Chemical] | | references | [1]. stsiapanava a, olsson u, wan m, et al. binding of pro-gly-pro at the active site of leukotriene a4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. proc natl acad sci u s a. 2014 mar 18;111(11):4227-32.
[2]. haeggstrm jz. leukotriene a4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene b4 biosynthesis. j biol chem. 2004 dec 3;279(49):50639-42.
[3]. snelgrove rj, jackson pl, hardison mt, et al. a critical role for lta4h in limiting chronic pulmonary neutrophilic inflammation. science. 2010 oct 1;330(6000):90-4. |
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