2-4-羧苯基四甲基咪唑烷-1-氧-3-氧化物
中文名称 | 2-4-羧苯基四甲基咪唑烷-1-氧-3-氧化物 |
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中文同义词 | 2 - (4 -羧基苯基)-4,4,5,5 -四甲基咪唑啉-3 -氧化钾盐;2-4-羧苯基四甲基咪唑烷-1-氧-3-氧化物;2-(4-羧基苯基)-4,4,5,5-四甲基咪唑啉-1-氧-3-氧化钾盐;羧基-PTIO 钾盐;化合物 T22623;PERFEMIKER]羧基-PTIO 钾盐,98% |
英文名称 | CARBOXY-PTIO |
英文同义词 | CARBOXY-PTIO;CARBOXY-PTIO POTASSIUM;2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYL-IMIDAZOLINE-1-OXYL-3-OXIDE POTASSIUM;2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, POTASSIUM SALT;2-(4-CARBOXYPHENYL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-1H-IMIDAZOL-1-YLOXY-3-OXIDE POTASSIUM;2-(4-CARBOXYPHENYL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-1H-IMIDAZOLYL-1-OXY-3-OXIDE, POTASSIUM SALT;2-(4-CARBOXYPHENYL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL, POTASSIUM SALT;2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt |
CAS号 | 148819-94-7 |
分子式 | C14H16KN2O4* |
分子量 | 315.39 |
EINECS号 | |
相关类别 | Nitric Oxide Reagents |
Mol文件 | 148819-94-7.mol |
结构式 |
2-4-羧苯基四甲基咪唑烷-1-氧-3-氧化物 性质
熔点 | 141-143°C |
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储存条件 | 2-8°C |
溶解度 | H2O: >20 mg/mL |
形态 | 固体 |
颜色 | 蓝色的 |
水溶解性 | Soluble in water. Also soluble in ethanol, methanol, DMSO or DMF. |
稳定性 | 供货时可稳定保存 2 年。 DMSO 或蒸馏水中的溶液可在 -20°C 下保存长达 1 个月。 |
CAS 数据库 | 148819-94-7(CAS DataBase Reference) |
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone.Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei.Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells .
Western Blot Analysis
Cell Line: | A375-S2 cells |
Concentration: | 200 μM |
Incubation Time: | 1 h prior to physalin A; 24 hours |
Result: | Diminished physalin A-induced procaspase-3 and PARP cleavage. |
Carboxy-PTIO (intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction and survival rate in Lps-treated rats. But it does not affect each parameter in naomal rats.
Animal Model: | SD rats |
Dosage: | 0.056-1.70 mg/kg/min |
Administration: | Intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min |
Result: | Exhibited a potent therapeutic value in endotoxin shock through the direct scavenging action against NO. |
安全信息
安全说明 | 24/25 |
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WGK Germany | 3 |
海关编码 | 2918999090 |
提供商 | 语言 |
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英文
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英文
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