2',5'-DIDEOXYADENOSINE
中文名称 | 2',5'-DIDEOXYADENOSINE |
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中文同义词 | 2',5'-二脱氧腺苷;2',5'-双脱氧腺苷;化合物2',5'-DIDEOXYADENOSINE;(2R,3S,5R)-5-(6-氨基-9H-嘌呤-9-基)-2-甲基四氢呋喃-3-醇;2',5'-二脱氧腺苷 |
英文名称 | 2',5'-DIDEOXYADENOSINE |
英文同义词 | 2',5'-DIDEOXYADENOSINE;2',5'-DD-ADO;5-(6-AMINOPURIN-9-YL)-2-METHYLTETRAHYDROFURAN-3-OL;(2R,3S,5R)-5-(6-aMino-9H-purin-9-yl)-2-Methyltetrahydrofuran-3-ol;NSC 95943;NSC 95943 2',5'-DIDEOXYADENOSINE;2',5'-Dideoxyadenosine >=95% (HPLC), solid;phosphoric acid [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-oxolanyl]methyl [hydroxy(phosphonooxy)phosphoryl] [(2R,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl] ester |
CAS号 | 6698-26-6 |
分子式 | C10H13N5O2 |
分子量 | 235.24 |
EINECS号 | |
相关类别 | 化学试剂;Adenylate cyclaseG Proteins and Cyclic Nucleotides;Adenylyl Cyclase Inhibitors;A to;Cyclic Nucleotide Metabolism;Enzyme Inhibitors by Enzyme |
Mol文件 | 6698-26-6.mol |
结构式 |
2',5'-DIDEOXYADENOSINE 性质
沸点 | 547.0±60.0 °C(Predicted) |
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密度 | 1.77±0.1 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 可溶于DMSO |
形态 | 固体 |
酸度系数(pKa) | 14.06±0.60(Predicted) |
颜色 | 白色 |
IC50: 3 µM (adenylyl cyclase)
2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448.
2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively.
Western Blot Analysis
Cell Line: | Primary hippocampal neurons |
Concentration: | 10 μM |
Incubation Time: | 30 min |
Result: | Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). |
2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K
+
and Cl
-
sparing effect of Fr•EtOAc in rats.
Animal Model: | Male Wistar rats (3-4 months old) |
Dosage: | 0.1 mg/kg |
Administration: | IP; 15 min pre-treated |
Result: | Fully inhibited the diuretic, natriuretic and K + and Cl - sparing effect of Fr•EtOAc in rats. |
安全信息
WGK Germany | 3 |
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海关编码 | 29349990 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-135878 | 2',5'-Dideoxyadenosine | 1 mg | 431元 | |
2024/04/30 | HY-135878 | 2',5'-DIDEOXYADENOSINE 2',5'-Dideoxyadenosine | 6698-26-6 | 5mg | 950元 |