| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Lythrine
CAS:5286-10-2
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| | cryogenine Basic information |
| Product Name: | cryogenine | | Synonyms: | Lythrine;20H-6,20-Methano-11,15-metheno-1H,8H-benzo[g]pyrido[2,1-d][1,5]oxaazacyclohexadecin-8-one, 2,3,4,4a,5,6-hexahydro-14-hydroxy-17,18-dimethoxy-, (4aS,6S,9Z,20S)- | | CAS: | 5286-10-2 | | MF: | C26H29NO5 | | MW: | 435.51216 | | EINECS: | | | Product Categories: | | | Mol File: | 5286-10-2.mol |  |
| | cryogenine Chemical Properties |
| Melting point | 241-2°C | | Boiling point | 655.4±55.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml | | form | A crystalline solid | | pka | 8.27±0.20(Predicted) |
| | cryogenine Usage And Synthesis |
| Description | This alkaloid is also present in Heimia salicifolia Link & Otto and is obtained as
long, glistening needles from either CH2Clr light petroleum or CH2Cl2-MeOH. It
is dextrorotatory with [α]25D + 40.6° (c 0.3, CHC13) and the ultraviolet spectrum
shows two absorption maxima at 260 and 284 mJ.1. The following salts and
derivatives have been prepared to characterize the base: the hydrochloride as
prisms, m.p. 325-331 °c (dec.); the acetyl derivative, m.p. In-3°C; [o:lf,S +
33.1 ° (c 0.75, CHC13) and the methyl ether, m.p. 239-24loC; the latter yielding
a crystalline hydrochloride and hydrobromide containing MeOH of crystalliza_x0002_tion. | | Description | Lythrine is an alkaloid originally isolated from H. salicifolia that inhibits prostaglandin synthetase (IC50 = 469 μM). | | Definition | ChEBI: (+)-Lythrine is a member of quinolizidines. | | References | Blomster, Schwarting, Bobbitt., LZoydia, 27, 15 (1964)
Douglas et aZ., ibid, 27, 25 (1964)
Crystal structure:
Zacharias et aZ., Experientia, 21, 247 (1965)
Stereochemistry:
Ferris, Boyce, Briner., J. Amer. Chern. Soc., 93,2942 (1971)
Ferris etaZ., ibid, 93,2963 (1971) |
| | cryogenine Preparation Products And Raw materials |
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