PHE-MET-ARG-PHE AMIDE
| 中文名称 | PHE-MET-ARG-PHE AMIDE |
|---|---|
| 中文同义词 | 神经肽 C;心脏兴奋肽;苯丙氨酸丙烯酰胺 |
| 英文名称 | FMRF AMIDE |
| 英文同义词 | MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE;MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE 1 1/2 ACOH 2H2O;MOLLUSCAN CARDIOEXCITATORY PEPTIDE;PHE-MET-ARG-PHE AMIDE;PHE-MET-ARG-PHE-NH2;PHE-MET-ARG-PHE-NH2 1/2ACOH 2H2O;6-O-?D-Glucopyranosyl-D-glucitol;L-PHENYLALANYL-L-METHIONYL-L-ARGINYL-L-PHENYLALANINAMIDE) |
| CAS号 | 64190-70-1 |
| 分子式 | C29H42N8O4S |
| 分子量 | 598.76 |
| EINECS号 | |
| 相关类别 | 细胞生物学 |
| Mol文件 | 64190-70-1.mol |
| 结构式 |  |
PHE-MET-ARG-PHE AMIDE 性质
| 密度 | 1.32±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | −20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 13.35±0.46(Predicted) |
ED50: 23 nM (K + current)
In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acts on K + channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide activates a novel K + current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe, amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe, amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM).
Phe-Met-Arg-Phe, amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min.
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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