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| | AGN 196996 Basic information |
| Product Name: | AGN 196996 | | Synonyms: | AGN 196996;VTP 196696;CS-1210;Benzoic acid, 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino]- | | CAS: | 958295-17-5 | | MF: | C24H20BrNO5 | | MW: | 482.32 | | EINECS: | | | Product Categories: | APIS | | Mol File: | 958295-17-5.mol |  |
| | AGN 196996 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder |
| | AGN 196996 Usage And Synthesis |
| Description | AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).
IC50 value: 2 nM(Ki)
Target: RARα antagonist
AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists. | | References | References:[1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62.
[2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8. |
| | AGN 196996 Preparation Products And Raw materials |
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