| Company Name: |
Chemleader Biomedical Co., Limited.
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| Tel: |
021-58180488 |
| Email: |
sales@MedChemLeader.com |
| Products Intro: |
Product Name:Maleimide-NH-PEG12-CH2CH2COOPFP Ester
Purity:97%+ Package:1g;5g;10g;50g;100g;500g;1kg Remarks:Biochemical Reagents; Pharmaceutical Intermediates
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| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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| Tel: |
010-60605840 |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:Mal-NH-PEG12-CH2CH2COOPFP ester
CAS:2136296-33-6
Purity:95% Package:100mg;250mg;1g
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| | Maleimide-NH-PEG12-CH2CH2COOPFP Ester Basic information |
| Product Name: | Maleimide-NH-PEG12-CH2CH2COOPFP Ester | | Synonyms: | Maleimide-NH-PEG12-CH2CH2COOPFP Ester;Mal-NH-PEG12-CH2CH2COOPFP ester;4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxa-40-azatritetracontanoic acid, 43-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-41-oxo-, 2,3,4,5,6-pentafluorophenyl ester | | CAS: | 2136296-33-6 | | MF: | C40H59F5N2O17 | | MW: | 934.89 | | EINECS: | | | Product Categories: | | | Mol File: | 2136296-33-6.mol |  |
| | Maleimide-NH-PEG12-CH2CH2COOPFP Ester Chemical Properties |
| Boiling point | 872.2±65.0 °C(Predicted) | | density | 1.272±0.06 g/cm3(Predicted) | | pka | 15.01±0.46(Predicted) |
| | Maleimide-NH-PEG12-CH2CH2COOPFP Ester Usage And Synthesis |
| Biological Activity | Mal-NH-PEG12-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Maleimide-NH-PEG12-CH2CH2COOPFP Ester Preparation Products And Raw materials |
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