(+)-川白芷内酯
| 中文名称 | (+)-川白芷内酯 |
|---|---|
| 中文同义词 | (+)-川白芷内酯;白花前胡素 B;白花前胡素 B,(+)-川白芷内酯;白花前胡丁素,(+)-川白芷内酯;白花前胡丁素标准品;白花前胡丁素对照品;(+)-白花前胡乙素;(9S,10S)-8,8-二甲基-2-氧代-9,10-二氢-2H,8H-吡喃并[2,3-F]苯并吡喃-9,10-二基 (2Z,2'Z)-双(2-甲基丁-2-烯酸酯) |
| 英文名称 | PDII |
| 英文同义词 | PDII;(2Z,2'Z)-2-Methyl-2-butenoic acid (9S,10S)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9,10-diyl ester;Bis[(Z)-2-methyl-2-butenoic acid](9S,10S)-2-oxo-8,8-dimethyl-9,10-dihydro-2H,8H-benzo[1,2-b:3,4-b']dipyran-9β,10β-diyl ester;Bis[(Z)-2-methyl-2-butenoic acid][(9S,10S)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran]-9,10-diyl ester;Praeruptorin B(b);2-Butenoic acid, 2-methyl-, (9S,10S)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9,10-diyl ester, (2Z,2'Z)-;8,8-dimethyl-9-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-9,10-dihydropyrano[2,3-f]chromen-10-yl](Z)-2-methylbut-2-enoate;(+)-Praeruptorin B |
| CAS号 | 73069-28-0 |
| 分子式 | C24H26O7 |
| 分子量 | 426.46 |
| EINECS号 | |
| 相关类别 | 对照品-中药对照品;标准品 -中药标准品;标准品，对照品;对照品 |
| Mol文件 | 73069-28-0.mol |
| 结构式 |  |
(+)-川白芷内酯 性质
| 熔点 | 175-176℃ |
|---|---|
| 沸点 | 524.8±50.0 °C(Predicted) |
| 密度 | 1.24 |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 粉末 |
| 稳定性 | 感光 |
SREBP.
Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B is found to powerfully decrease the SRE-luciferase activity, and this effect is dose dependent. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantlytly down-regulates the expression of SREBP-1c and SREBP-2 . Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9.
The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle treated mice, although they are still heavier than the chow diet-fed mice, suggesting that Praeruptorin B can ameliorate diet-induced obesity (DIO). More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar as lovastatin. In addition, compared with vehicle treated mice, Praeruptorin B significantly lowers the level of TC and TG in liver, comparable to lovastatin. The staining results reveal that Praeruptorin B-treated mice exhibit less lipid accumulation than that of vehicle treated mice. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B.