|
|
| | saikogenin A Basic information |
| Product Name: | saikogenin A | | Synonyms: | Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,4α,16β)-;Clinopodiside A1;Saikogenin A,inhibit,Inhibitor,DPP,1166100,Dipeptidyl Peptidase | | CAS: | 5092-09-1 | | MF: | C30H48O4 | | MW: | 472.7 | | EINECS: | | | Product Categories: | | | Mol File: | 5092-09-1.mol |  |
| | saikogenin A Chemical Properties |
| Melting point | 287-293 °C | | Boiling point | 607.4±55.0 °C(Predicted) | | density | 1.16±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 14.47±0.70(Predicted) |
| | saikogenin A Usage And Synthesis |
| Biological Activity | Saikogenin A, extracted from the traditional Chinese medicine Bupleurum, is a dipeptidyl peptidase IV (DPP-IV) inhibitor. | | in vitro | Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide. | | in vivo | Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. It is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema . The anti-inflammatory action of it are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation. | | target | |
| | saikogenin A Preparation Products And Raw materials |
|