地拉卓二盐酸盐
| 中文名称 | 地拉卓二盐酸盐 |
|---|---|
| 中文同义词 | 地拉卓二盐酸盐;1,4-双[3-(3,4,5-三甲氧基苯甲酰氧基)丙基]高哌嗪二盐酸盐;(1,4-二氮杂环庚烷-1,4-二基)双(丙烷-3,1-二基) 双(3,4,5-三甲氧基苯甲酸酯) 二盐酸盐;盐酸地拉卓 |
| 英文名称 | DILAZEP DIHYDROCHLORIDE |
| 英文同义词 | DILAZEP DIHYDROCHLORIDE;1,4-BIS[3-(3,4,5-TRIMETHOXYBENZOYLOXY)PROPYL]HOMOPIPERAZINE DIHYDROCHLORIDE;N,N'-BIS[3-(3,4,5-TRIMETHOXY-BENZOYLOXY)PROPYL]HOMOPIPER-AZINE DIHYDROCHLORIDE;1,4-bis(3-(3,4,5-trimethoxybenzoyloxy)-propyl)perhydro-1,4-diazepinedihydroc;astac;astac4898;benzoicacid,3,4,5-trimethoxy-,diesterwithtetrahydro-1h-1,4-diazepine-1,4(5;comelian |
| CAS号 | 20153-98-4 |
| 分子式 | C31H46Cl2N2O10 |
| 分子量 | 677.61 |
| EINECS号 | 243-548-8 |
| 相关类别 | |
| Mol文件 | 20153-98-4.mol |
| 结构式 |  |
地拉卓二盐酸盐 性质
| 熔点 | 194-198° (monohydrate) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 在水中的溶解度10 mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 100 mM in water |
Adenosine uptake
The uptake mechanism has been studied extensively in vitro and Dilazep, NBI and Dipyridamole have been reported to inhibit the uptake of adenosine into different cells. Of these compounds, Dilazep and NBI are almost 10 times more potent than Dipyridamole. In addition, only Dilazep is water soluble and no solubility aiding organic solvent is needed for preparing an aqueous solution.
After administration of Dilazep, even low doses (0.04-0.1 mg/kg/min) of exogenous adenosine significantly increases superior mesenteric arterial conductance (SMAC) and elevates arterial plasma adenosine concentration. The increased adenosine levels were highly correlated with the increased percentage of change of SMAC and values for R
max
and EC
50
were 193.4% change of SMAC and 2.8 μM, respectively. Administration of bolus doses of 8-phenyltheophylline abolishes the ability of Dilazep to potentiate vasodilation, but did not affect isoproterenol-induced relaxation.
Dilazep inhibits the phospholipase activation in reperfused heart mitochondria and also inhibits the lipid peroxidation caused by cerebral ischemia and reperfusion. Dilazep may prevent ischemic cerebral injury due to an increase in cerebral blood flow and/or its protective effects on vascular endothelial cell membrane.
安全信息
| 提供商 | 语言 |
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英文
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