VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) manufacturers
|
| | VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) Basic information |
| Product Name: | VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) | | Synonyms: | H-PHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2;PHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2;VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT);VIP (6-28) (HUMAN, RAT, PORCINE, BOVINE);VASOACTIVE INTESTINAL PEPTIDE (6-28) (HUMAN, BOVINE, PORCINE, RAT);VASOACTIVE INTESTINAL PEPTIDE (6-28), HUMAN, PORCINE, RAT;VASOACTIVE INTESTINAL PEPTIDE FRAGMENT 6-28 PORCINE;vasoactive intestinal peptide*fragment 6-28 porci | | CAS: | 69698-54-0 | | MF: | C126H207N37O34S | | MW: | 2816.28 | | EINECS: | | | Product Categories: | VIP and PACAP receptor;Peptide Receptors | | Mol File: | 69698-54-0.mol |  |
| | VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) Chemical Properties |
| storage temp. | −20°C | | form | Powder | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | H-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
| | VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) Usage And Synthesis |
| Biological Activity | VIP(6-28)(human, rat, porcine, bovine) is a potent exogenous vasoactive intestinal peptide (VIP) antagonist. | | in vitro | VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) is an effective VIP antagonist in the superior cervical ganglion (SCG) , and results obtained using this analog indicate that endogenous VIP can participate in a positive feedback loop in injured sympathetic neurons in which it enhances its own expression. VIP(6-28), when added to short-term cultures of adult SCG at a concentration of 10, 30, or 100 μM, reduces the increase in cAMP levels produced by stimulation with 10 μM VIP by 52, 64, or 81%, respectively. At any of these concentrations tested, VIP(6-28) by itself does not alter cAMP levels. In contrast to its ability to reduce the VIP-stimulated elevation in cAMP levels by 64%, the addition of 30 μM VIP(6-28) to culture medium does not significantly alter cAMP levels measured after stimulation of adult ganglia with either isoproterenol or forskolin (10 μM each). Similar results on the ability of VIP(6-28) to block VIP -stimulated increases in cAMP levels are obtained in neuron-enriched and in non-neuronal cell-en riched dissociated cultures. | | target | |
| | VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) Preparation Products And Raw materials |
|