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| | kopsine Basic information |
| Product Name: | kopsine | | Synonyms: | kopsine;3-Hydroxy-22-oxokopsan-1-carboxylic acid methyl ester;6H,13aH-3a,5a-Ethano-5,11-methano-1H-indolizino[8,1-cd]carbazole-6-carboxylic acid, 2,3,4,5,11,12-hexahydro-5-hydroxy-14-oxo-, methyl ester, (3aR,5S,5aS,10bR,11R,13aS)- (9CI) | | CAS: | 559-48-8 | | MF: | C22H24N2O4 | | MW: | 380.44 | | EINECS: | | | Product Categories: | | | Mol File: | 559-48-8.mol |  |
| | kopsine Chemical Properties |
| Melting point | 220°C (dec.). | | alpha | D27 -14.3 ± 1° (c = 2 in chloroform) |
| | kopsine Usage And Synthesis |
| Description | The major constituent of Kopsia !ruticosa, this base has [α]D - 17.5° (c 2.15,
CHC13). It forms a series of crystalline salts and derivatives, e.g. the aurichloride,
m.p. 203-5°C (dec.); perchlorate, m.p. 284°C (dec.); picrate, m.p. 230°C (dec.)
and methiodide, m.p. 200°C (dec.). It may be reduced to the dihydro derivative
which has m.p. 218°C. When fused with NaOH the alkaloid furnishes 2-
methylindole and 2-indole-2-carboxylic acid. | | References | Bhattacharya et al., 1. Amer. Chem. Soc., 71,3370 (1949)
Spiteller et al., Naturwiss., 49, 279 (1962)
Govindachari et al., Helv. Chim. Acta, 45, 1146 (1962)
Govindachari et al., ibid, 46, 433, 572 (1963)
Battersby, Gregory.,J. Chern. Soc., 22 (1963) |
| | kopsine Preparation Products And Raw materials |
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