CINANSERIN HYDROCHLORIDE CAS#: 54-84-2

CINANSERIN HYDROCHLORIDE

生物活性靶点体外研究体内研究用途与合成方法 MSDS CINANSERIN HYDROCHLORIDE价格(试剂级) 上下游产品信息

中文名称	CINANSERIN HYDROCHLORIDE
中文同义词	N-(2-((3-(二甲氨基)丙基)硫代)苯基)-3-苯基丙烯酰胺盐酸盐;化合物CINANSERIN HYDROCHLORIDE
英文名称	CINANSERIN HYDROCHLORIDE
英文同义词	2'-(3-DIMETHYLAMINOPROPYL-THIO)-CINNAMANILIDE HYDROCHLORIDE;N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE;N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE HYDROCHLORIDE;2’-((3-(dimethylamino)propyl)thio)-cinnamanilidmonohydrochloride;maptc;n-(2-((3-(dimethylamino)propyl)thio)phenyl)-3-phenyl-2-propenamidmonohyd;sq10,643;DPTC 2'-(3-Dimethylaminopropylthio)cinnamanilide hydrochloride
CAS号	54-84-2
分子式	C20H25ClN2OS
分子量	376.94
EINECS号
相关类别	amino
Mol文件	54-84-2.mol
结构式

CINANSERIN HYDROCHLORIDE 性质

密度	1.22 g/cm3
储存条件	Inert atmosphere,Store in freezer, under -20°C
溶解度	DMSO：125 mg/mL（331.62 mM；需要超声）
形态	粉末
水溶解性	Soluble to 50 mM in water

CINANSERIN HYDROCHLORIDE 用途与合成方法

生物活性

Cinanserin hydrochloride (SQ 10643) 是一种有效，选择性和高度亲和力的 5-HT2 受体拮抗剂，Ki 为 41 nM。Cinanserin hydrochloride 对 5-HT2 的结合亲和力比对 5-HT1 受体 (Ki 为 3500 nM) 的结合亲和力高得多。Cinanserin hydrochloride 还是严重急性呼吸系统综合症冠状病毒的 3C 样蛋白酶 (3C-like proteinase) 的抑制剂，可大大减少体外的病毒复制。

靶点

5-HT ₂ Receptor

41 nM (Ki)

3C-like proteinase

体外研究

Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CL ^pro , HCoV-229E 3CL ^pro , with the K _D values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CL ^pro and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CL ^pro .
The IC ₅₀ values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CL ^pro are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC ₅₀ values for HCoV-229E 3CL ^pro are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3C ^pro at concentrations up to 200 μM.

体内研究

Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.

Animal Model:	Male Wistar rats (250 g) underwent thermal injury
Dosage:	5 mg/kg
Administration:	Intravenous injection; for 2 hours
Result:	Significantly reduced systemic burn edema to shamburn levels..

安全信息

海关编码	2921490090

MSDS信息

CINANSERIN HYDROCHLORIDE 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-100943	Cinanserin hydrochloride		5 mg	1593元
2024/04/30	HY-100943	CINANSERIN HYDROCHLORIDE Cinanserin hydrochloride	54-84-2	10mg	2550元

CINANSERIN HYDROCHLORIDE