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| | TG100801 Basic information |
| Product Name: | TG100801 | | Synonyms: | TG100801;Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]-, 1-benzoate;4-Chloro-3-[5-methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-1,2,4-benzotriazin-7-yl]phenol 1-benzoate;4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-amino)benzo[e][1,2,4]triazin-7-yl)p;4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenyl benzoate;4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-amino)benzo[e][1,2,4]triazin-7-y;TG100801;TG-100801 | | CAS: | 867331-82-6 | | MF: | C33H30ClN5O3 | | MW: | 580.08 | | EINECS: | | | Product Categories: | | | Mol File: | 867331-82-6.mol |  |
| | TG100801 Chemical Properties |
| Boiling point | 747.9±70.0 °C(Predicted) | | density | 1.310 | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | pka | 9.59±0.20(Predicted) |
| | TG100801 Usage And Synthesis |
| Biological Activity | tg100801 is a multi-kinases inhibitor. it is a pro-drug version of tg100572. [1]tg100572 inhibits several growth factor receptors in addition to src family kinases. tg100801 significantly inhibited laser-induced cnv in mice, and suppressed fluorescein leakage from the vasculature and retinal thickening measured by optical coherence tomography in a rat model or retinal vein occlusion. tg100801 may play as a new topically applied treatment approach for ocular neovascularization and retinal edema. the highest concentration of tg100801 was found at the front of the rat eye (conjunctiva and cornea). [1] | | target | VEGFR1 | | references | 1. doukas j, mahesh s, umeda n et al. topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. j cell physiol. 2008 jul;216(1):29-37. |
| | TG100801 Preparation Products And Raw materials |
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