| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:ZK118182 isopropyl ester
CAS:154927-31-8
Purity:98% Package:1G;10G;100G Remarks:ZK118182 is a prostaglandin (PG) analog that exhibits potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM).
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:ZK118182 isopropyl ester
CAS:154927-31-8
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:ZK118182isopropylester
CAS:154927-31-8
Purity:NULL Package:100g;250g Remarks:NULL
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| | ZK118182 isopropyl ester Basic information |
| Product Name: | ZK118182 isopropyl ester | | Synonyms: | ZK118182 isopropyl ester;Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI);propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate;ZK118182 isopropyl ester Exclusive;QLJUNFBXIBNQOL-LMJZMJOFSA-N;ZK118182 isopropyl ester,ZK-118182 isopropyl ester | | CAS: | 154927-31-8 | | MF: | C23H37ClO5 | | MW: | 428.99 | | EINECS: | | | Product Categories: | | | Mol File: | 154927-31-8.mol |  |
| | ZK118182 isopropyl ester Chemical Properties |
| Boiling point | 553.1±50.0 °C(Predicted) | | density | 1.14±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml | | pka | 14.22±0.70(Predicted) |
| | ZK118182 isopropyl ester Usage And Synthesis |
| Description | Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid. |
| | ZK118182 isopropyl ester Preparation Products And Raw materials |
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