| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:Kif15-IN-1
CAS:672926-32-8
Purity:>98% Package:2170RMB/2mg
|
| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:Kif15-IN-1
CAS:672926-32-8
Purity:>98% Package:2170RMB/2mg
|
|
| | Kif15-IN-1 Basic information |
| Product Name: | Kif15-IN-1 | | Synonyms: | Kif15-IN-1;2-[[(2S)-2-(1,4-Dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester;Kif15 inhibitor 1;5-Thiazolecarboxylic acid, 2-[[(2S)-2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-, ethyl ester;Kif-15-IN-1,Kif15IN1,Kif15 IN 1 | | CAS: | 672926-32-8 | | MF: | C20H22N4O5S | | MW: | 430.48 | | EINECS: | | | Product Categories: | | | Mol File: | 672926-32-8.mol |  |
| | Kif15-IN-1 Chemical Properties |
| density | 1.361±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; insoluble in DMSO; ≥19.2 mg/mL in EtOH | | pka | 7.73±0.50(Predicted) |
| | Kif15-IN-1 Usage And Synthesis |
| Biological Activity | kif15-in-1, a potent kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].kif15,also known as kinesin-12 and hklp2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.kif15 is involved in maintaining bipolar microtubulespindle apparatusin dividing cells and shares redundant functions with kif11 [3]. | | references | [1]. preparation of quinazolinediones as kif15 kinesin inhibitors for treating cellular proliferative disorders. pat. appl. publ. (2004), us 20040053948 a1 20040318.
[2]. buster d w, baird d h, yu w, et al. expression of the mitotic kinesin kif15 in postmitotic neurons: implications for neuronal migration and development[j]. journal of neurocytology, 2003, 32(1): 79-96.
[3]. vanneste d, takagi m, imamoto n, et al. the role of hklp2 in the stabilization and maintenance of spindle bipolarity[j]. current biology, 2009, 19(20): 1712-1717. |
| | Kif15-IN-1 Preparation Products And Raw materials |
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