RO 15-4513
中文名称 | RO 15-4513 |
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中文同义词 | 化合物 T16775 |
英文名称 | RO 15-4513 |
英文同义词 | RO 15-4513;8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER;ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester;8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester;Azidomazenil;Ethyl 8-azido-6-dihyro-5-methyl-6-oxo-4H-imidazo[1,5-A][1,4]benzodiazepine-3-carboxylic acid ethyl ester;4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester |
CAS号 | 91917-65-6 |
分子式 | C15H14N6O3 |
分子量 | 326.32 |
EINECS号 | |
相关类别 | GABA/Glycine receptor |
Mol文件 | 91917-65-6.mol |
结构式 |
RO 15-4513 性质
储存条件 | Desiccate at +4°C |
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溶解度 | 45%(w/v)aq2-羟丙基-β-环糊精:0.8 mg/mL |
形态 | 固体 |
颜色 | 棕褐色 |
CAS 数据库 | 91917-65-6 |
BZR; ethanol;
Ro15-4513 usually acts as a partial inverse agonist at GABA A receptors, except an agonist for α4 and α6 subunit-containing ones.
Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) completely inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing.
Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABA
A
receptor δ subunit-deficient mice.
Animal Model: | Male C57BL/6J mice |
Dosage: | 3 mg/kg |
Administration: | I.p.; 10 min before being tested |
Result: | Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing. |
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-103476 | RO 15-4513 Ro15-4513 | 91917-65-6 | 1mg | 710元 |
2024/04/30 | HY-103476 | RO 15-4513 Ro15-4513 | 91917-65-6 | 5mg | 1350元 |