Urotensin II (114-124), human TFA
| 中文名称 | Urotensin II (114-124), human TFA |
|---|---|
| 中文同义词 | |
| 英文名称 | Urotensin II (114-124), human TFA |
| 英文同义词 | Urotensin II (114-124), human TFA |
| CAS号 | |
| 分子式 | C??H??F?N??O??S? |
| 分子量 | 0 |
| EINECS号 | |
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| Mol文件 | Mol File |
| 结构式 |
Urotensin II (114-124), human TFA 性质
Urotensin II (114-124), human TFA 是一个含 11 个氨基酸的残基肽，是孤儿受体 GPR14 激动剂，是一有效血管收缩剂。
GPR14
Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC 50 =0:62±0.17 nM, n=6).
Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction.