Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
Products Intro: |
Product Name:L-858,051 (hydrochloride) CAS:115116-37-5 Purity:>98% Package:1mg;10mg;50mg;100mg;
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
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marketing@tsbiochem.com |
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Product Name:L-858,051 (hydrochloride);L858,051 (hydrochloride),L 858,051 (hydrochloride) CAS:115116-37-5 Purity:98% Package:25 mg
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Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
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Product Name:L-858,051 (hydrochloride) CAS:115116-37-5 Purity:95% Package:500μg;1mg;5mg
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Company Name: |
Cayman Chemical Company
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(800) 364-9897 |
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cayman@caymanchem.com |
Products Intro: |
Product Name:L-858,051 (hydrochloride) CAS:115116-37-5
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| L-858051 Basic information |
Product Name: | L-858051 | Synonyms: | 8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL;7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL;L-858051;FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE;L-858,051 (hydrochloride);L858,051 (hydrochloride),L 858,051 (hydrochloride) | CAS: | 115116-37-5 | MF: | C29H50Cl2N2O7 | MW: | 609.62 | EINECS: | | Product Categories: | | Mol File: | Mol File | |
| L-858051 Chemical Properties |
storage temp. | Store at -20°C | solubility | DMF: 20 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 5 mg/ml | form | A crystalline solid |
| L-858051 Usage And Synthesis |
Description | L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase.1 L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes.2 L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.3,4,5 | References | 1. Laurenza, A., Khandelwal, Y., De Souza, N.J., et al. Stimulation of adenylate cyclase by water-soluble analogues of forskolin Mol. Pharmacol. 32(1),133-139(1987). 2. Joost, H.G., Habberfield, A.D., Simpson, I.A., et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action Mol. Pharmacol. 33(4),449-453(1988). 3. Funaki, C., Hodges, R.R., and Dartt, D.A. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland Am. J. Physiol. Cell Physiol. 293(5),C1551-C1560(2007). 4. Luo, S.-F., Chiu, C.-T., Tsao, H.-L., et al. Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells Cell. Signal. 9(2),159-167(1997). 5. Haj Slimane, Z., Bedioune, I., Lechêne, P., et al. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes Cardiovasc. Res. 102(1),97-106(2014). |
| L-858051 Preparation Products And Raw materials |
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