Amino-PEG4-Val-Cit-PAB-MMAE manufacturers
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| Product Name: | Amino-PEG4-Val-Cit-PAB-MMAE | | Synonyms: | Amino-PEG4-Val-Cit-PAB-MMAE;Amino-PEG4-Val-Cit-PAB-MMAE USP/EP/BP;L-Valinamide, N-[[[4-[[N-(15-amino-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-... | | CAS: | 1492056-71-9 | | MF: | C69H115N11O17 | | MW: | 1370.71 | | EINECS: | | | Product Categories: | ADC LINKER | | Mol File: | Mol File | ![Amino-PEG4-Val-Cit-PAB-MMAE Structure]() |
| | Amino-PEG4-Val-Cit-PAB-MMAE Chemical Properties |
| Boiling point | 1339.0±65.0 °C(Predicted) | | density | 1.171±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 13.29±0.70(Predicted) |
| | Amino-PEG4-Val-Cit-PAB-MMAE Usage And Synthesis |
| Uses | Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | | In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | | Storage | Please store the product under the recommended conditions in the Certificate of Analysis. | | Description | Amino-PEG4-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains an amino-PEG4 spacer, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. |
| | Amino-PEG4-Val-Cit-PAB-MMAE Preparation Products And Raw materials |
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