匹伐加宾
| 中文名称 | 匹伐加宾 |
|---|---|
| 中文同义词 | 匹伐加宾;4-新戊酰氨基丁酸 |
| 英文名称 | Pivagabine |
| 英文同义词 | 4-[(2,2-dimethylpropionyl)amino]butyric acid;4-(Pivaloylamino)butanoic acid;4-PivalaMidobutanoic acid;CXB 722;PG 2 (pharmaceutical);Tonerg;Butanoic acid,4-[(2,2-diMethyl-1-oxopropyl)aMino]-;Pivagabine |
| CAS号 | 69542-93-4 |
| 分子式 | C9H17NO3 |
| 分子量 | 187.24 |
| EINECS号 | 274-038-3 |
| 相关类别 | |
| Mol文件 | 69542-93-4.mol |
| 结构式 |  |
匹伐加宾 性质
| 沸点 | 397.0±25.0 °C(Predicted) |
|---|---|
| 密度 | 1.053±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 4.66±0.10(Predicted) |
Pivagabine (CXB 722) 是具有神经调节活性的疏水性4-氨基丁酸衍生物。Pivagabine 能穿透大鼠的血脑屏障。Pivagabine 拮抗足部休克对大鼠脑内 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions.
| Animal Model: | Adult male Sprague-Dawley CD rats (200-250 g) |
| Dosage: | 200 mg/kg |
| Administration: | i.p.; twice a day for 4 days and 1 hour before killing on the 5th day |
| Result: | Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-108295 | 匹伐加宾 Pivagabine | 69542-93-4 | 5mg | 800元 |
| 2024/04/30 | HY-108295 | 匹伐加宾 Pivagabine | 69542-93-4 | 10mg | 1300元 |