1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷
| 中文名称 | 1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷 |
|---|---|
| 中文同义词 | 1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷;1-(3,4-二氯苯基)-3-氮杂二环[3.1.0]己烷;化合物 T11087;化合物DOV-216,303 FREE BASE |
| 英文名称 | 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane |
| 英文同义词 | 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane;DOV216303;3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-;DOV-216,303 (Free Base);1-(3,4-dichlorophenyl)-3-azabicyclo(3.1.0)hexane 11H11Cl2N;303 Free Base;DOV-216;inhibit,SLC6A4,Serotonin Transporter,DOV 216,303 Free Base,5-HTT,DAT,DOV-216,303,SERT,Dopamine Transporter,SLC6A3,Inhibitor,DOV216,303 Free Base |
| CAS号 | 66504-40-3 |
| 分子式 | C11H11Cl2N |
| 分子量 | 228.12 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 66504-40-3.mol |
| 结构式 | ![1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷 结构式](CAS/GIF/66504-40-3.gif) |
1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷 性质
| 沸点 | 324.4±37.0 °C(Predicted) |
|---|---|
| 密度 | 1.371 |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：≥ 125 mg/mL (547.96 mM)；水：< 0.1 mg/mL（不溶） |
| 酸度系数(pKa) | 10.45±0.40(Predicted) |
DOV-216,303 (Free Base) 是有效的 5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂，其对 hSERT、hNET 和 hDAT 的 IC50 值分别为 14 nM，20 nM和78 nM。在嗅球切除大鼠模型中，可增加前额皮质中单胺的释放及具有抗抑郁的作用。
IC50: 14 nM (serotonin), 20 nM (norepinephrine), 78 nM (dopamine).
Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals.
Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations.
| Animal Model: | Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery. |
| Dosage: | 20 mg/kg. |
| Administration: | I.P. daily for 17days. |
| Result: | Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations. |
| Animal Model: | Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery. |
| Dosage: | 20 mg/kg. |
| Administration: | I.P. once. |
| Result: | Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-18332C | DOV-216,303 Free Base | 1 mg | 1333元 | |
| 2024/04/30 | HY-18332C | 1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷 DOV-216,303 Free Base | 66504-40-3 | 5mg | 3500元 |