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| Product Name: | ML298 | | Synonyms: | ML298;Benzamide, 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-;ML298 >=98% (HPLC);CID53393915;ML-298,Inhibitor,ML 298,Phospholipase,inhibit;3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-benzamide | | CAS: | 1426916-02-0 | | MF: | C22H23F3N4O2 | | MW: | 432.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1426916-02-0.mol |  |
| | ML298 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml | | form | powder | | color | white to beige |
| | ML298 Usage And Synthesis |
| Description | ML-298 is an inhibitor of phospholipase D2 (PLD2; IC50 = 355 nM). It is selective for PLD2 over PLD1 (IC50 = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 μM without inducing cytotoxicity. | | Uses | ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2). | | Biochem/physiol Actions | ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2; IC50 = 355 nM). ML298 does not affect PLD1 activity at concentrations up to 20 μM. |
| | ML298 Preparation Products And Raw materials |
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