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| | DDD85646 Basic information |
| Product Name: | DDD85646 | | Synonyms: | DDD85646;DDD 85646
(DDD85646);Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;DDD85646 Hydrochloride;African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide | | CAS: | 1215010-55-1 | | MF: | C21H24Cl2N6O2S | | MW: | 495.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1215010-55-1.mol |  |
| | DDD85646 Chemical Properties |
| Melting point | >215°C (dec.) | | Boiling point | 684.3±65.0 °C(Predicted) | | density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly, Heated), Methanol (Slightly) | | form | Solid | | pka | 7.04±0.50(Predicted) | | color | Off-White to Yellow |
| | DDD85646 Usage And Synthesis |
| Description | DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM). | | Uses | DDD85646 is a potent inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT). |
| | DDD85646 Preparation Products And Raw materials |
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