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(-)-BICUCULLINE METHBROMIDE

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Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:(-)-Bicuculline methobromide
CAS:66016-70-4
Purity:>=98%(HPLC) Package:$103.9/10mg;$435.9/50mg;Bulk package Remarks:98%(HPLC)
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:1(S),9(R)-()-Bicuculline methbromide
CAS:66016-70-4
Purity:>= 98 % HPLC, solid Package:25mg, 125mg Remarks:B7561
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:1(S),9(R)-()-Bicuculline methbromide
CAS:66016-70-4
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，More
Company Name: Riedel-de Haen AG  
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Products Intro: Product Name:1(S),9(R)-()-Bicuculline methbromide
CAS:66016-70-4
Company Name: SIGMA-RBI  
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(-)-BICUCULLINE METHBROMIDE Basic information
Product Name:(-)-BICUCULLINE METHBROMIDE
Synonyms:(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1);1(S),9(R)-(-)-Bicuculline methbromide;(-)-BICUCULLINE METHBROMIDE;[r-(r*,s*)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquindinium bromide;1(s),9(r)-(-)-bicuculline methobromide;(6R)-6-[(5S)-6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
CAS:66016-70-4
MF:C21H20NO6.Br
MW:462.294
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Mol File:66016-70-4.mol
(-)-BICUCULLINE METHBROMIDE Structure
(-)-BICUCULLINE METHBROMIDE Chemical Properties
storage temp. 2-8°C
solubility aqueous base: unstable
form solid
color white
Water Solubility Soluble to 50 mM in water
Safety Information
Hazard Codes T+,N
Risk Statements 24-28-50
Safety Statements 24/25-61-45-36/37-28
RIDADR UN 1544 6.1/PG 2
WGK Germany 3
MSDS Information
(-)-BICUCULLINE METHBROMIDE Usage And Synthesis
Uses1(S),9(R)-(-)-Bicuculline methbromide has been used:
  • as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
  • in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
  • in hypothalamic explant cultures

Biochem/physiol Actions1(S),9(R)-(?)-Bicuculline methbromide is a GABAA receptor antagonist, which blocks Ca2+-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline.
storageStore at RT
(-)-BICUCULLINE METHBROMIDE Preparation Products And Raw materials
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