氨甲酰甲胆碱
| 中文名称 | 氨甲酰甲胆碱 |
|---|---|
| 中文同义词 | 氨甲酰甲胆碱-D6;氨甲酰甲胆碱;苯乙二酚-D6 |
| 英文名称 | BETHANECHOL |
| 英文同义词 | 1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-;Ammonium, (2-hydroxypropyl)trimethyl-, carbamate (ester) (8CI);Carbamoyl-β-methylcholine;Carbamyl-β-methylcholine;BETHANECOL |
| CAS号 | 674-38-4 |
| 分子式 | C7H17N2O2+ |
| 分子量 | 161.22 |
| EINECS号 | 209-686-8 |
| 相关类别 | |
| Mol文件 | 674-38-4.mol |
| 结构式 |  |
氨甲酰甲胆碱 性质
Bethanechol 是一种拟副交感神经剂。Bethanechol 是毒蕈碱型受体 (mAChR) 的激动剂，通过直接刺激副交感神经系统的 mAChR (M1、M2、M3、M4、M5) 发挥其作用。
mAChR
Bethanechol (0.3-300 μM) significantly reduces ileal pacemaker potentials, significantly.
Bethanechol (2-12 mg/kg; i.p.) induces drinking and increased urine output of rats in a dose-dependent fashion.
| Animal Model: | Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) |
| Dosage: | 2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg). |