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MedChemexpress LLC
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| Products Intro: |
Product Name:RS4317
CAS:91431-42-4
Purity:300RMB/1mg Package:>98%
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| | Methotrexate Basic information |
| Product Name: | Methotrexate | | Synonyms: | 6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate;RS-43197;RS4317;Lonapalene;RS 43179;RS4317 (Lonapalene);Lopalene;1,4-Naphthalenediol, 6-chloro-2,3-dimethoxy-, 1,4-diacetate | | CAS: | 91431-42-4 | | MF: | C16H15ClO6 | | MW: | 338.74 | | EINECS: | | | Product Categories: | | | Mol File: | 91431-42-4.mol |  |
| | Methotrexate Chemical Properties |
| Melting point | 93-94° (Jones); mp 87.5-89.5° (Perri, Moore) | | Boiling point | 424.9±45.0 °C(Predicted) | | density | 1.309±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | Methotrexate Usage And Synthesis |
| Originator | Lonapalene,Syntex | | Uses | Antipsoriatic. | | Definition | ChEBI: Lonapalene is an organochlorine compound and a member of naphthalenes. | | Manufacturing Process | A solution of sodium nitrate (0.69 g, 10 mmol) in water (5 ml) was added at
0-5°C to a solution of 6-amino-2,3-dimethoxy-1,4-naphthoquinone (1.17 g, 5
mmol) in 5:1 acetic acid:water (25 ml) containing concentrated hydrochloric
acid (1.7 ml). A further quantity of sodium nitrite (0.69 g) was then added to
the reaction mixture after cooling to -5°C, followed by a solution of cuprous
chloride (0.6 g) in concentrated hydrochloric acid (5 ml). The mixture was
allowed to warm to room temperature and solid cuprous chloride was added
portionwise until the mixture assumed a green color. Water was then added to
the reaction mixture and the precipitated yellow solid filtered off, washed with
water and recrystallized from methanol:water (2:1) giving 1.01 g of 6-chloro-
2,3-dimethoxy-1,4-naphthoquinone, melting point 93-94°C (from etherpetrolium ether). | | Therapeutic Function | Antipsoriatic |
| | Methotrexate Preparation Products And Raw materials |
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