安三烯菌素B
| 中文名称 | 安三烯菌素B |
|---|---|
| 中文同义词 | 安三烯菌素B;安莎三烯 B |
| 英文名称 | mycotrienin II |
| 英文同义词 | mycotrienin II;20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate];T 23II, Mycotrienin II, T 23II;D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester |
| CAS号 | 82189-04-6 |
| 分子式 | C36H50N2O8 |
| 分子量 | 638.79 |
| EINECS号 | |
| 相关类别 | 微生物代谢物 |
| Mol文件 | 82189-04-6.mol |
| 结构式 |  |
安三烯菌素B 性质
| 储存条件 | -20°C |
|---|---|
| 溶解度 | 溶于DMSO、DMF、乙醇或甲醇 |
| 形态 | 固体 |
| 颜色 | 淡黄色 |
| 稳定性 | 在 -20°C 下的DMSO、DMF、乙醇或甲醇溶液中保存长达 3 个月。 |
Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.5 μg/ml, 12.5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively. Ansatrienin B inhibits the release of 45 calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC 50 ) value of 21 nM.Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC 50 =58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC 50 of 300 nM.
Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD 50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice.