Company Name: |
Haoyuan Chemexpress Co., Ltd.
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Tel: |
021-58950125 |
Email: |
info@chemexpress.com |
Products Intro: |
Product Name:Vercirnon CAS:698394-73-9 Purity:>98% Package:3500RMB/5mg
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GSK-1605786 manufacturers
- Vercirnon
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- $1.00 / 1KG
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2019-12-23
- CAS:698394-73-9
- Min. Order: 1g
- Purity: Min98% HPLC
- Supply Ability: g/kg /ton
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| GSK-1605786 Basic information |
Product Name: | GSK-1605786 | Synonyms: | GSK 1605786;GSK1605786;GSK-1605786;Vercirnon;Vercirnon GSK1605786;4-(2-(4-tert-butylphenylsulfonamido)-5-chlorobenzoyl)pyridin-1(2H)-olate;Benzenesulfonamide, N-[4-chloro-2-[(1-oxido-4-pyridinyl)carbonyl]phenyl]-4-(1,1-dimethylethyl)-;CCX282-B | CAS: | 698394-73-9 | MF: | C22H21ClN2O4S | MW: | 444.93 | EINECS: | | Product Categories: | | Mol File: | 698394-73-9.mol | |
| GSK-1605786 Chemical Properties |
Boiling point | 672.3±65.0 °C(Predicted) | density | 1.29±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO: 25 mg/ml | form | A crystalline solid | pka | 7.07±0.10(Predicted) |
| GSK-1605786 Usage And Synthesis |
Description | Vercirnon is an orally bioavailable antagonist of chemokine receptor 9 (CCR9) with an IC50 value of 5.4 nM for inhibition of CCL25-induced calcium mobilization in Molt-4 cells. It is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 μM for all). It also inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively), as well as chemotaxis of human T cells stimulated by retinoic acid (RA) and mouse and rat thymocytes. Vercirnon binds allosterically to the intracellular side of CCR9 and prevents G protein coupling. |
| GSK-1605786 Preparation Products And Raw materials |
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