| Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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| Tel: |
028-81700200 18116577057 |
| Email: |
3003855609@qq.com |
| Products Intro: |
Product Name:(SRS)-AHPC-PEG6-C4-Cl
CAS:1835705-59-3
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
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| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:(S,R,S)-AHPC-PEG6-C4-Cl
CAS:1835705-59-3
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
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E3 ligase Ligand-Linker Conjugates 9 manufacturers
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| | E3 ligase Ligand-Linker Conjugates 9 Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 9 | | Synonyms: | E3 ligase Ligand-Linker Conjugates 9;VH032-PEG6-C4-Cl;VHL Ligand-Linker Conjugates 10;L-Prolinamide, N-(24-chloro-1-oxo-3,6,9,12,15,18-hexaoxatetracos-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(S,R,S)-AHPC-2-2-2-2-2-2-6-Cl | | CAS: | 1835705-59-3 | | MF: | C40H63ClN4O10S | | MW: | 827.46702 | | EINECS: | | | Product Categories: | | | Mol File: | 1835705-59-3.mol |  |
| | E3 ligase Ligand-Linker Conjugates 9 Chemical Properties |
| Boiling point | 963.4±65.0 °C(Predicted) | | density | 1.195±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Ethanol: 100 mg/mL (120.85 mM); DMSO: ≥ 100 mg/mL (120.85 mM) | | pka | 13.54±0.46(Predicted) |
| | E3 ligase Ligand-Linker Conjugates 9 Usage And Synthesis |
| Uses | Protein degrader builiding block (S,R,S)-AHPC-PEG6-Butyl chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| | E3 ligase Ligand-Linker Conjugates 9 Preparation Products And Raw materials |
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