6-MITC; 6 MITC; 6MITC
| 中文名称 | 6-MITC; 6 MITC; 6MITC |
|---|---|
| 中文同义词 | 化合物 T15474;1-异硫氰基-6-(甲基亚磺酰基)-己烷 |
| 英文名称 | 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE |
| 英文同义词 | 6-METHYLSULFINYLHEXYL ISOTHIOCYANATE;1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE;6-HITC;6-MITC;6-MITC; 6 MITC; 6MITC;Hexane, 1-isothiocyanato-6-(methylsulfinyl)- |
| CAS号 | 4430-35-7 |
| 分子式 | C8H15NOS2 |
| 分子量 | 205.34 |
| EINECS号 | |
| 相关类别 | 制剂-抑制剂;Aliphatics, Sulfur & Selenium Compounds |
| Mol文件 | Mol File |
| 结构式 |  |
6-MITC; 6 MITC; 6MITC 性质
| 沸点 | 385.9±25.0 °C(Predicted) |
|---|---|
| 密度 | 1.12±0.1 g/cm3(Predicted) |
| 储存条件 | Refrigerator, under inert atmosphere |
| 溶解度 | 氯仿（微溶）、甲醇（微溶） |
| 形态 | 油状 |
| 颜色 | 无色至淡黄色 |
| LogP | 0.959 (est) |
Nrf2
Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) is an active compound in wasabi ( Wasabia japonica Matsum.). Whether Hesperin induces cytotoxicity of HUVECs is determined. More than 1 μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL, to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs.
Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) activates Nrf2 and induces phase II enzyme genes but this induction is absent in Nrf2-null mice, suggesting that Hesperin is a potential activator of the Nrf2/ARE-dependent detoxification pathway. To determine whether Hesperin ameliorates hepatic steatosis and iron accumulation, wild-type and Nrf2-null mice are fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus Hesperin (10 mg/kg/day ip), 4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron), 5) HFD/Iron plus Hesperin. The HFD increased hepatic triglycerides in both genotypes and Hesperin suppress increased hepatic triglycerides in wild-type mice but do not reduce these triglycerides in Nrf2-null mice.